Seminars in Perinatology
Volume 34, Issue 3 , Pages 231-234 , June 2010

Phototherapy for Neonatal Jaundice—Therapeutic Effects on More Than One Level?

  • Thor Willy Ruud Hansen, MD, PhD

      Affiliations

    • Neonatal Intensive Care Unit, Women's and Children's Clinic, Oslo University Hospital-Rikshospitalet, Oslo, Norway
    • Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    • Corresponding Author InformationAddress reprint requests to Thor Willy Ruud Hansen, MD, PhD, Neonatal Intensive Care Unit, Women's and Children's Clinic, Oslo University Hospital-Rikshospitalet, N-0027 Oslo, Norway

References 

  1. Metlinger B: Ein Regiment der Jungen Kinder. Augsburg, Günther Zainer, 1473
  2. Hervieux JFE. De l'ictère des Nouveau-nés. Paris, France: Thèse; 1847;
  3. Orth J. Ueber das Vorkommen von Bilirubinkrystallen bei neugeborenen Kindern. Virchows Arch Pathol Anat. 1875;63:447–462
  4. Schmorl C. Zur Kenntnis des Ikterus neonatorum, insbesondere der dabei auftretenden Gehirnveränderungen. Verh Dtsch Pathol Ges. 1904;6:109–115
  5. Diamond LK, Allen FH, Thomas WO. Erythroblastosis fetalis (VII. Treatment with exchange transfusion). N Engl J Med. 1951;244:39–49
  6. Hsia DY, Allen F, Gellis SS, et al. Erythroblastosis fetalis (VIII. Prevention of kernicterus). N Engl J Med. 1952;246:668–671
  7. Mollison PL, Cutbush M. Haemolytic disease of the newborn. In:  Gairdner D editors. Recent Advances in Pediatrics. New York, NY: P Blakiston and Son; 1954;p. 110–132
  8. Watchko JF, Oski F. Bilirubin 20 mg/dl = Vigintifobia. Pediatrics. 1983;71:660–663
  9. Dobbs RH, Cremer RJ. Phototherapy. Arch Dis Child. 1975;50:833–836
  10. Cremer RJ, Perryman PW, Richards DH. Influence of light on the hyperbilirubinaemia of infants. Lancet. 1958;1:1094–1097
  11. Maisels MJ, McDonagh AF. Phototherapy for neonatal jaundice. N Engl J Med. 2008;358:920–928
  12. Brown AK, Kim MH, Wu PY, et al. Efficacy of phototherapy in prevention and management of neonatal hyperbilirubinemia. Pediatrics. 1985;75:393–400
  13. AAP. Subcommittee on hyperbilirubinemia: Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114:297–316
  14. McDonagh AF, Lightner DA. Like a shriveled blood orange (Bilirubin, jaundice and phototherapy). Pediatrics. 1985;75:443–455
  15. Ebbesen F. Recurrence of kernicterus in term and near-term infants in Denmark. Acta Paediatr. 2000;89:1213–1217
  16. Hansen TWR. Pioneers in the scientific study of neonatal jaundice and kernicterus. Pediatrics. 2000;106:e15
  17. Penn AA, Enzmann DR, Hahn JS, et al. Kernicterus in a full term infant. Pediatrics. 1994;93:1003–1006
  18. Yokochi K. Magnetic resonance imaging in children with kernicterus. Acta Paediatr. 1995;84:937–939
  19. Volpe JJ. Neurology of the Newborn. (ed 5).. Philadelphia, PA: Elsevier; 2008;
  20. Hansen TWR. The pathophysiology of bilirubin toxicity. In:  Maisels MJ,  Watchko JF editor. Neonatal Jaundice. London: United Kingdom, Harwood Academic Publishers; 2000;p. 89–104
  21. Watchko JF, Daood MJ, Hansen TWR. Brain bilirubin content is increased in P-glycoprotein deficient transgenic null mutant mice. Pediatr Rev. 1998;44:763–766
  22. Silberberg DH, Johnson L, Schutta H, et al. Effects of photodegradation products of bilirubin on myelinating cerebellum cultures. J Pediatr. 1970;77:613–618
  23. Thaler MM. Toxic effects of bilirubin and its photodecomposition products. Birth Defects Orig Arts Series. 1970;6:128–130
  24. Porto SO. In vitro and in vivo studies on the effect of phototherapy upon bilirubin. Birth Defects Orig Arts Series. 1970;6:83–89
  25. Kaul R, Bajpai VK, Shipstone AC, et al. Bilirubin-induced erythrocyte membrane cytotoxicity. Exp Mol Pathol. 1981;34:290–298
  26. Calligaris SD, Bellarosa C, Giraudi P, et al. Cytotoxicity is predicted by unbound and not total bilirubin concentration. Pediatr Rev. 2007;62:576–580
  27. Nakamura H, Lee Y, Uetani Y, et al. Effects of phototherapy on serum unbound bilirubin in icteric newborn infants. Biol Neonate. 1981;39:295–299
  28. Tan KL. The pattern of bilirubin response to phototherapy for neonatal hyperbilirubinemia. Pediatr Rev. 1982;16:670–674
  29. Hansen TWR. Acute management of extreme neonatal jaundice—The potential benefits of intensified phototherapy and interruption of enterohepatic bilirubin circulation. Acta Paediatr. 1997;86:843–846
  30. Onishi S, Isobe K, Itoh S, et al. Metabolism of bilirubin and its photoisomers in newborn infants during phototherapy. J Biochem. 1986;100:789–795
  31. Myara A, Sender A, Valette V, et al. Early changes in cutaneous bilirubin and serum bilirubin isomers during intensive phototherapy of jaundiced neonates with blue and green light. Biol Neonate. 1997;71:75–82
  32. Mreihil K, McDonagh A, Nakstad B, et al. Early isomerization of bilirubin in intensive phototherapy of neonatal jaundice. Pediatr Acad Soc Baltimore MD USA. May, 2009;
  33. Tan KL, Skurr BA, Yip YY. Phototherapy and the brain-stem auditory evoked response in neonatal hyperbilirubinemia. J Pediatr. 1992;120:306–308
  34. Johnson L, Brown AK, Bhutani VK. System-based approach to management of neonatal jaundice and prevention of kernicterus. J Pediatr. 2002;140:396–403
  35. Harris MC, Bernbaum JC, Polin JR, et al. Developmental follow-up of breastfed term and near-term infants with marked hyperbilirubinemia. Pediatrics. 2001;107:1075–1080
  36. Hansen TWR, Nietsch L, Norman E, et al. Apparent reversibility of acute intermediate phase bilirubin encephalopathy. Acta Paediatr. 2009;98:1689–1694
  37. McDonagh AF. Ex uno plures: The concealed complexity of bilirubin species in neonatal blood samples. Pediatrics. 2006;118:1185–1187

PII: S0146-0005(10)00022-4

doi: 10.1053/j.semperi.2010.02.008

Seminars in Perinatology
Volume 34, Issue 3 , Pages 231-234 , June 2010

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