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Seminars in Perinatology
Volume 34, Issue 3
, Pages 211-221
, June 2010
Mechanisms of Inflammatory Lung Injury in the Neonate: Lessons from a Transgenic Mouse Model of Bronchopulmonary Dysplasia
References
- Very low birthweight, bronchopulmonary dysplasia and health in early childhood. Acta Paediatr. 1999;88:1385–1391
- Long-term pulmonary sequelae of severe bronchopulmonary dysplasia. J Pediatr. 1998;133:193–200
- Trends in neonatal morbidity and mortality for very low birthweight infants. Am J Obstet Gynecol. 2007;196:e141–e148
- Neonatal chronic lung disease in extremely immature baboons. Am J Respir Crit Care Med. 1999;160:1333–1346
- Lung lavage of newborns with respiratory distress syndrome (Prolonged neutrophil influx is associated with bronchopulmonary dysplasia). Chest. 1983;83:31S–33S
- Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome (Role of inflammation in the pathogenesis of bronchopulmonary dysplasia). J Clin Invest. 1983;72:656–666
- . Inflammation and bronchopulmonary dysplasia: A continuing story. Semin Fetal Neonatal Med. 2006;11:354–362
- Blood cytokines during the perinatal period in very preterm infants: Relationship of inflammatory response and bronchopulmonary dysplasia. J Pediatr. 2009;154:39–43e33
- Cytokines associated with bronchopulmonary dysplasia or death in extremely low birthweight infants. Pediatrics. 2009;123:1132–1141
- Antenatal endotoxin and glucocorticoid effects on lung morphometry in preterm lambs. Pediatr Review. 2000;48:782–788
- Maternal exposure to endotoxin delays alveolarization during postnatal rat lung development. Am J Physiol Lung Cell Mol Physiol. 2009;296:L726–L737
- Antenatal infection in the rabbit impairs post-natal growth and lung alveolarisation. Eur Respir J. 2008;32:1520–1528
- Increase in interleukin (IL)-1 beta and IL-6 in bronchoalveolar lavage fluid obtained from infants with chronic lung disease of prematurity. Pediatr Review. 1996;40:250–256
- . IL-1beta disrupts postnatal lung morphogenesis in the mouse. Am J Respir Cell Mol Biol. 2007;36:32–42
- Early alterations of growth factor patterns in bronchoalveolar lavage fluid from preterm infants developing bronchopulmonary dysplasia. Pediatr Review. 2010;67:83–89
- . Matrix metalloproteinase-9 in lung remodeling. Am J Respir Cell Mol Biol. 2003;28:12–24
- . Matrix metalloproteinase-2 (MMP-2) and MMP-9 in pulmonary pathology. Exp Lung Res. 2005;31:599–621
- Low levels of tissue inhibitors of metalloproteinases with a high matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio are present in tracheal aspirate fluids of infants who develop chronic lung disease. Pediatrics. 2004;113:1709–1714
- The role of matrix metalloproteinases -9 and -2 in development of neonatal chronic lung disease. Acta Paediatr. 2004;93:791–796
- Chorioamnionitis and increased neonatal lung lavage fluid matrix metalloproteinase-9 levels: Implications for antenatal origins of chronic lung disease. Am J Obstet Gynecol. 2003;188:871–875
- Early increased levels of matrix metalloproteinase-9 in neonates recovering from respiratory distress syndrome. Biol Neonate. 2006;89:6–14
- Increased lung matrix metalloproteinase-9 levels in extremely premature baboons with bronchopulmonary dysplasia. Pediatr Pulmonol. 2005;39:5–14
- Role of matrix metalloprotease-9 in hyperoxic injury in developing lung. Am J Physiol Lung Cell Mol Physiol. 2008;295:L584–L592
- . Hyperoxia decreases matrix metalloproteinase-9 and increases tissue inhibitor of matrix metalloproteinase-1 protein in the newborn rat lung: Association with arrested alveolarization. Pediatr Rev. 2004;56:26–34
- Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2008;294:L535–L543
- Matrix metalloproteinase_9 deficiency worsens lung injury in a model of bronchopulmonary dysplasia. Am J Respir Cell Mol Biol. 2009;41:59–68
- . Role of transforming growth factor-beta in tissue injury and repair. Proc Soc Exp Biol Med. 1997;214:27–40
- Increase in the concentration of transforming growth factor beta-1 in bronchoalveolar lavage fluid before development of chronic lung disease of prematurity. J Pediatr. 1996;128:464–469
- Bioactive transforming growth factor-beta in the lungs of extremely low birthweight neonates predicts the need for home oxygen supplementation. Biol Neonate. 2000;77:217–223
- Transfer of the active form of transforming growth factor-beta 1 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia. Am J Pathol. 2003;163:2575–2584
- Conditional overexpression of bioactive transforming growth factor-beta1 in neonatal mouse lung: A new model for bronchopulmonary dysplasia?. Am J Respir Cell Mol Biol. 2004;31:650–656
- Antenatal inflammation induced TGF-beta1 but suppressed CTGF in preterm lungs. Am J Physiol Lung Cell Mol Physiol. 2007;292:L223–L231
- TGF-beta is a critical mediator of acute lung injury. J Clin Invest. 2001;107:1537–1544
- The integrin alpha v beta 6 binds and activates latent TGF beta 1: A mechanism for regulating pulmonary inflammation and fibrosis. Cell. 1999;96:319–328
- Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling. J Cell Sci. 1995;108:2241–2251
- Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res. 2008;102:804–812
- Hogmalm A, Sheppard D, Lappalainen U, et al: Beta6 integrin subunit deficiency alleviates lung injury in a mouse model of bronchopulmonary dysplasia. Am J Respir Cell Mol Biol, in press
- . Expression of the Ym2 lectin-binding protein is dependent on interleukin (IL)-4 and IL-13 signal transduction: Identification of a novel allergy-associated protein. J Biol Chem. 2001;276:41969–41976
- Role of eosinophil chemotactic factor by T lymphocytes on airway hyperresponsiveness in a murine model of allergic asthma. Am J Respir Cell Mol Biol. 2006;35:103–109
- . Intrauterine infection and preterm delivery. N Engl J Med. 2000;342:1500–1507
- Amniotic fluid interleukin-6: Correlation with upper genital tract microbial colonization and gestational age in women delivered after spontaneous labor versus indicated delivery. Am J Obstet Gynecol. 1995;173:606–612
- . Preterm birth and periodontal disease. N Engl J Med. 2006;355:1925–1927
- . Pneumonia in pregnancy. Crit Care Med. 2005;33:S390–S397
- An experimental model for intraamniotic infection and preterm labor in rhesus monkeys. Am J Obstet Gynecol. 1994;171:1660–1667
- Ureaplasma parvum or Mycoplasma hominis as sole pathogens cause chorioamnionitis, preterm delivery, and fetal pneumonia in rhesus macaques. Reprod Sci. 2009;16:56–70
- . Transforming growth factor-beta 2 prevents preterm delivery induced by interleukin-1alpha and tumor necrosis factor-alpha in the rabbit. Am J Obstet Gynecol. 1993;168:1318–1322
- Preterm labor is induced by intraamniotic infusions of interleukin-1beta and tumor necrosis factor-alpha but not by interleukin-6 or interleukin-8 in a nonhuman primate model. Am J Obstet Gynecol. 2006;195:1578–1589
- Elevated amniotic fluid interleukin-6 levels during the early second trimester are associated with greater risk of subsequent preterm delivery. Am J Reprod Immunol. 1997;37:227–231
- Elevated second-trimester amniotic fluid interleukin-6 levels predict preterm delivery. Am J Obstet Gynecol. 1998;178:546–550
- Mycoplasma hominis and Ureaplasma urealyticum in midtrimester amniotic fluid: Association with amniotic fluid cytokine levels and pregnancy outcome. Am J Obstet Gynecol. 2004;191:1382–1386
- Detection of Ureaplasma urealyticum in second-trimester amniotic fluid by polymerase chain reaction correlates with subsequent preterm labor and delivery. J Infect Dis. 2003;187:518–521
- Choriodecidual inflammation: A harbinger of the preterm labor syndrome. Reprod Sci. 2010;17:85–94
- . Atypical chronic lung disease patterns in neonates. Pediatrics. 1999;103:759–765
- Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops. Pediatrics. 1996;97:210–215
- The Alabama preterm birth study: Polymorphonuclear and mononuclear cell placental infiltrations, other markers of inflammation, and outcomes in 23 to 32-week preterm newborn infants. Am J Obstet Gynecol. 2006;195:803–808
- Outcome of neonates less than 30 weeks gestation with histologic chorioamnionitis. Am J Perinatol. 2005;22:155–159
- Cord immunoproteins as predictors of respiratory outcome in preterm infants. Am J Obstet Gynecol. 2009;200:e101–e108
- Preterm histologic chorioamnionitis: Impact on cord gas and pH values and neonatal outcome. Am J Obstet Gynecol. 2006;195:1357–1365
- . Maternal versus fetal inflammation and respiratory distress syndrome: A 10-year hospital cohort study. Arch Dis Child Fetal Neonatal Ed. 2009;94:F13–F16
- . Intraamniotic interleukin-1 accelerates surfactant protein synthesis in fetal rabbits and improves lung stability after premature birth. J Clin Invest. 1997;99:2992–2999
- Effects of antenatal endotoxin and glucocorticoids on the lungs of preterm lambs. Am J Obstet Gynecol. 2000;182:401–408
- Experimental amniotic fluid infection in sheep: Effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep. Am J Obstet Gynecol. 2008;198:e121–e128
- The relationship between placental histopathology findings and perinatal outcome in preterm infants. J Matern Fetal Neonatal Med. 2003;13:102–109
- Inflammatory markers in intrauterine and fetal blood and cerebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infants. Pediatr Review. 2004;55:1009–1017
- Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. Am J Obstet Gynecol. 1997;177:825–830
- . Chorioamnionitis/funisitis and the development of bronchopulmonary dysplasia. J Paediatr Child Health. 2004;40:356–359
- . Placental and other perinatal risk factors for chronic lung disease in very low birthweight infants. Pediatr Rev. 2002;52:713–719
- Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants. J Pediatr. 2002;140:171–176
- Necrotizing funisitis: Clinical significance and association with chronic lung disease in premature infants. Am J Obstet Gynecol. 1997;177:1402–1407
- . Intrauterine inflammation, neonatal sepsis, and chronic lung disease: A 13-year hospital cohort study. Pediatrics. 2009;123:1314–1319
- . Maternal IL-1beta production prevents lung injury in a mouse model of bronchopulmonary dysplasia. Am J Respir Cell Mol Biol. 2010;42:149–160
This work was supported by the Swedish Medical Research Council (K.B.), the Swedish Heart and Lung Foundation (K.B.), the Frimurare Barnhus Foundation (K.B.), the Swedish Government Grants for Medical Research (K.B.), and the Queen Silvia Children's Hospital Research Foundation (A.H. and E.B.).
PII: S0146-0005(10)00020-0
doi: 10.1053/j.semperi.2010.02.006
© 2010 Elsevier Inc. All rights reserved.
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Seminars in Perinatology
Volume 34, Issue 3
, Pages 211-221
, June 2010
