Seminars in Perinatology
Volume 34, Issue 3 , Pages 201-206 , June 2010

Basic Consciousness of the Newborn

  • Hugo Lagercrantz, MD, PhD

      Affiliations

    • Neonatal Research Unit, Karolinska Institute, Astrid Lindgren Children's Hospital, Stockholm, Sweden
    • Corresponding Author InformationAddress reprint requests to Hugo Lagercrantz, MD, PhD, Neonatal Research Unit, Karolinska Institute, Astrid Lindgren Children′s Hospital, 171 76 Stockholm, Sweden
    • ,
  • Jean-Pierre Changeux, PhD

      Affiliations

    • Département de Neuroscience, Institut Pasteur, Paris Cedex, Paris, France

References 

  1. Fellman V, Hellström-Westas L, Norman M, et al. One-year survival of extremely preterm infants after active perinatal care in Sweden (EXPRESS Group). J Am Med Assoc. 2009;301:2225–2233
  2. Lagercrantz H. The emergence of the mind—A borderline of human viability?. Acta Paediatr. 2007;96:327–328
  3. Searle JR. Consciousness. Annu Rev Neurosci. 2000;23:557–578
  4. Koch C. The Quest for Consciousness: A Neurobiological Approach. Eaglewood, CO: Roberts and Company; 2004;
  5. Laureys S, Tononi G. The Neurology of Consciousness. London: Academic Press, Elsevier; 2008;
  6. Lagercrantz H, Changeux J-P. The emergence of human consciousness: From fetal to neonatal life. Pediatr Review. 2009;65:255–260
  7. Dehaene S, Kerszberg M, Changeux JP. A neuronal model of a global workspace in effortful cognitive tasks. Proc Natl Acad Sci U S A. Nov 24, 1998;95:14529–14534
  8. Changeux J-PaDS. The neuronal workspace model: Conscious processing and learning. In:  Menzel R editors. Learning and Memory: A Comprehensive Reference. Oxford: Elsevier; 2008;p. 1–35
  9. Damasio AR. Investigating the biology of consciousness. Philos Trans R Soc Lond. 1998;353:1879-1852
  10. Bhardwaj RD, Curtis MA, Spalding KL, et al. Neocortical neurogenesis in humans is restricted to development. Proc Natl Acad Sci U S A. 2006;103:12564–12568
  11. Kostovic I, Jovanov-Milosevic N. The development of cerebral connections during the first 20-45 weeks' gestation. Semin Fetal Neonatal Med. 2006;11:415–422
  12. Vanhatalo S, Lauronen L, Sep N. Back to bedside with basic science. Semin Fetal Neonatal Med. 2006;11:464–470
  13. Fransson P, Skiold B, Horsch S, et al. Resting-state networks in the infant brain. Proc Natl Acad Sci U S A. 25, 2007;104:15531–15536
  14. Fransson P, Skiold B, Engstrom M, et al. Spontaneous brain activity in the newborn brain during natural sleep-an fMRI study in infants born at full term. Pediatr Res. 2009;66:301–305
  15. Fox MD, Raichle M. Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci. 2007;8:700–711
  16. Bartocci M, Bergqvist LL, Lagercrantz H, et al. Pain activates cortical areas in the preterm newborn brain. Pain. 2006;122:109–117
  17. Slater R, Cantarella A, Gallella S, et al. Cortical pain responses in human infants. J Neurosci. 5, 2006;26:3662–3666
  18. Schaal B, Hummel T, Soussignan R. Olfaction in the fetal and premature infant: Functional status and clinical implications. Clin Perinatol. 2004;31:261–285vi-vii
  19. Varendi H, Porter RH, Winberg J. The effect of labor on olfactory exposure learning within the first postnatal hour. Behav Neurosci. 2002;116:206–211
  20. Bartocci M, Winberg J, Ruggiero C, et al. Activation of olfactory cortex in newborn infants after odor stimulation: A functional near-infrared spectroscopy study. Pediatr Rev. 2000;48:18–23
  21. Bartocci M, Winberg J, Papendieck G, et al. Cerebral hemodynamic response to unpleasant odors in the preterm newborn measured by near-infrared spectroscopy. Pediatr Rev. 2001;50:324–330
  22. Smotherman WP. Classical conditioning in the rat fetus: Temporal characteristics and behavioral correlates of the conditioned response. Dev Psychobiol. 2002;40:116–130
  23. Johnson MH. Subcortical face processing. Nat Rev Neurosci. 2005;6:766–774
  24. Adolphs R. Cognitive neuroscience of human social behaviour. Nat Rev Neurosci. 2003;4:165–178
  25. Lowery CL, Eswaran H, Murphy P, et al. Fetal magnetoencephalography. Semin Fetal Neonatal Med. 2006;11:430–436
  26. Gray L, Philbin MK. Effects of the neonatal intensive care unit on auditory attention and distraction. Clin Perinatol. 2004;31:243–260vi
  27. Mellor DJ, Diesch TJ, Gunn AJ, et al. The importance of “awareness” for understanding fetal pain. Brain Res Brain Res Rev. 2005;49:455–471
  28. Vanhatalo S, Kaila K. Development of neonatal EEG activity: From phenomenology to physiology. Semin Fetal Neonatal Med. 2006;11:471–478
  29. Lagercrantz H, Slotkin TA. The “stress” of being born. Sci Am. 1986;254:100–107
  30. Rochat P. Five levels of self-awareness as they unfold early in life. Conscious Cogn. 2003;12:717–731
  31. Meltzoff AN, Moore MK. Imitation of facial and manual gestures by human neonates. Science. 1977;198:75–787
  32. Decety J, Jackson PL. The functional architecture of human empathy. Behav Cogn Neurosci Rev. 2004;3:71–100
  33. Soltis J. The signal functions of early infant crying. Behav Brain Sci. 2004;27:443–458discussion:459-490
  34. Als H, Lawhon G, Duffy FH, et al. Individualized developmental care for the very low-birth-weight preterm infant (Medical and neurofunctional effects). J Am Med Assoc. 1994;272:853–858

 Supported by The EU seventh Framework.

PII: S0146-0005(10)00018-2

doi: 10.1053/j.semperi.2010.02.004

Seminars in Perinatology
Volume 34, Issue 3 , Pages 201-206 , June 2010

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