Seminars in Perinatology
Volume 34, Issue 3 , Pages 188-192 , June 2010

Low Birth Weight Infants and the Developmental Programming of Hypertension: A Focus on Vascular Factors

  • Isabelle Ligi, MD

      Affiliations

    • Service de Médecine Néonatale, Centre Hospitalier Universitaire La Conception, Marseille, France
    • Aix-Marseille Université, Marseille, F-13385, France
    • Inserm U608, Marseille, F-13385, France
    • ,
  • Isabelle Grandvuillemin, MD

      Affiliations

    • Service de Médecine Néonatale, Centre Hospitalier Universitaire La Conception, Marseille, France
    • Aix-Marseille Université, Marseille, F-13385, France
    • Inserm U608, Marseille, F-13385, France
    • ,
  • Virginie Andres, MD

      Affiliations

    • Service de Médecine Néonatale, Centre Hospitalier Universitaire La Conception, Marseille, France
    • ,
  • Françoise Dignat-George, PhD

      Affiliations

    • Aix-Marseille Université, Marseille, F-13385, France
    • Inserm U608, Marseille, F-13385, France
    • Laboratoire d'Hématologie, Centre Hospitalier Universitaire La Conception, Marseille, France
    • ,
  • Umberto Simeoni, MD

      Affiliations

    • Service de Médecine Néonatale, Centre Hospitalier Universitaire La Conception, Marseille, France
    • Aix-Marseille Université, Marseille, F-13385, France
    • Inserm U608, Marseille, F-13385, France
    • Corresponding Author InformationAddress reprint requests to Umberto Simeoni, MD

References 

  1. Kistner A, Celsi G, Vanpee M, et al. Increased systolic daily ambulatory blood pressure in adult women born preterm. Pediatr Nephrol. 2005;20:946–953
  2. Siewert-Delle A, Ljungman S. The impact of birthweight and gestational age on blood pressure in adult life: A population-based study of 49-year-old men. Am J Hypertens. 1998;11:946–953
  3. Bonamy AK, Bendito A, Martin H, et al. Preterm birth contributes to increased vascular resistance and higher blood pressure in adolescent girls. Pediatr Res. 2005;58:845–849
  4. Johansson S, Iliadou A, Bergvall N, et al. Risk of high blood pressure among young men increases with the degree of immaturity at birth. Circulation. 2005;112:3430–3436
  5. Nijland MJ, Ford SP, Nathanielsz PW. Prenatal origins of adult disease. Curr Opin Obstet Gynecol. 2008;20:132–138
  6. Barker DJP, Osmond C, Winter PD, et al. Weight in infancy and death from ischaemic heart disease. Lancet. 1989;2:577–580
  7. Ojeda NB, Grigore D, Alexander BT. Intrauterine growth restriction: Fetal programming pf hypertension and kidney disease. Adv Chronic Kidney Dis. 2008;15:101–106
  8. Nuyt AM. Mechanisms underlying developmental programming of elevated blood pressure and vascular dysfunction: Evidence from human studies and experimental animal models. Clin Sci. 2008;114:1–17
  9. Nuyt AM, Alexander BT. Developmental programming and hypertension. Curr Opin Nephrol Hypertens. 2009;18:144–152
  10. Meaume S, Rudnichi A, Lynch A, et al. Aortic pulse wave velocity as a marker of cardiovascular disease in subjects over 70 years old. J Hypertens. 2001;19:871–877
  11. Lurbe E, Torro MI, Carvajal E, et al. Birth weight impacts on reflections in children and adolescents. Hypertension. 2003;41:646–650
  12. Oren A, Vos LE, Bos WJW, et al. Gestational age and birth weight in relation to aortic stiffness in healthy young adults: Two separate mechanisms?. Am J Hypertens. 2003;16:76–79
  13. Tauzin L, Rossi P, Giusano B, et al. Characteristics of arterial stiffness in very low birth weight premature infants. Pediatr Res. 2006;60:592–596
  14. Skilton MR, Griffiths KA, Harmer JA, et al. Aortic wall thickness in newborns with intrauterine growth restriction. Lancet. 2005;365:1484–1486
  15. Jiang B, Godfrey KM, Martyn CN, et al. Birth weight and cardiac structure in children. Pediatrics. 2006;117:e257–e261
  16. Martyn CN, Greenwald SE. Impaired synthesis of elastin in walls of aorta and large conduit arteries during early development as an initiating event in pathogenesis of systemic hypertension. Lancet. 1997;350:953–955
  17. Khorram N, Momeni M, Desai M, et al. Nutrient restriction in utero induces remodeling of the vascular extracellular matrix in rat offspring. Reprod Sci. 2007;14:73–80
  18. Berry CL, Looker T. An alteration in the chemical structure of the aortic wall induced by a finite period of growth inhibition. J Anat. 1973;109:285–298
  19. Burkhardt T, Matter CM, Lohmann C, et al. Decreased umbilical artery compliance and IGF-I plasma levels in infants with intrauterine growth restriction (Implications for fetal programming of hypertension). Placenta. 2009;30:136–141
  20. Kistner A, Jacobson L, Jacobson SH, et al. Low gestational age associated with abnormal retinal vascularization and increased blood pressure in adult women. Pediatr Res. 2002;51:675–680
  21. Hellstrom A, Dahlgren J, Marsal K, et al. Abnormal retinal vascular morphology in young adults following intrauterine growth restriction. Pediatrics. 2004;113:e77–e80
  22. Hellstrom A, Hard AL, Niklasson A, et al. Abnormal retinal vascularisation in preterm children as a general vascular phenomenom. Lancet. 1998;352:1827
  23. Mitchell P, Liew G, Rochtchina E, et al. Evidence of arteriolar narrowing in low birth weight children. Circulation. 2008;118:518–524
  24. Pladys P, Sennlaub F, Brault S, et al. Microvascular rarefaction and decreased angiogenesis in rats with fetal programming of hypertension associated with exposure to a low-protein diet in utero. Am J Physiol Regul Integr Comp Physiol. 2005;289:R1580–R1588
  25. Khorram O, Khorram N, Momeni M, et al. Maternal undernutrition inhibits angiogenesis in the offspring: A potential mechanism of programmed hypertension. Am J Physiol Regul Integr Comp Physiol. 2007;293:745–753
  26. Martin H, Gazelus B, Norman M. Impaired Acetylcholine-induced vascular relaxation in low birth weight infants: Implications for adult hypertension?. Pediatr Res. 2000;47:457–462
  27. Norman M, Martin H. Preterm birth attenuates association between low birth weight and endothelial dysfunction. Circulation. 2003;108:996–1001
  28. Leeson CPM, Whincup PH, Cook DG, et al. Flow-mediated dilation in 9- to 11-year-old children: The influence of intrauterine and childhood factors. Circulation. 1997;96:2233–2238
  29. Brawley L, Poston L, Hanson MA. Mechanisms underlying the programming of small artery dysfunction (Review of the model using low protein diet in pregnancy in the rat). Arch Physiol Biochem. 2003;111:23–25
  30. Holemans K, Gerber R, Meurrens K, et al. Maternal food restriction in the second half of pregnancy affects vascular function but not blood pressure of rat female offspring. Br J Nutr. 1999;81:73–79
  31. Lamireau D, Nuyt AM, Hou X, et al. Altered vascular function in fetal programming of hypertension. Stroke. 2002;33:2292–2298
  32. Franco MCP, Arruda RM, Kawamoto EM, et al. Intrauterine undernutrition: Expression and activity of the endothelial nitric oxide synthase in male and female adult offspring. Cardiovasc Res. 2002;56:145–153
  33. Bobadilla RA, Henkel CC, Escalante B, et al. Possible involvement of endothelium-derived hyperpolarizing factor in vascular responses of abdominal aorta from pregnant rats. Hypertension. 1997;30:596–602
  34. Payne JA, Alexander BT, Khalil RA. Reduced endothelial vascular relaxation in growth-restricted offspring of pregnant rats with reduced uterine perfusion. Hypertension. 2003;42:768–774
  35. Franco MCP, Dantas APV, Akamine HE, et al. Enhanced oxidative stress as a potential mechanism underlying the programming of hypertension in utero. J Cardiovasc Pharmacol. 2002;40:501–509
  36. Gil FZ, Lucas SRR, Gomes GN, et al. Effects of intrauterine food restriction and long-term dietary supplementation with L-arginine on age-related changes in renal function and structure of rats. Pediatr Res. 2005;57:724–731
  37. Hill JM, Zalos G, Halcox JPJ, et al. Circulation of endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med. 2003;348:593–600
  38. Sugawara J, Mitsui-Saito M, Hayashi C, et al. Decrease and senescence of endothelial progenitor cells in patients with preeclampsia. J Clin Endocrinol Metab. 2005;90:5329–5332
  39. Ingram DA, Lien IZ, Mead LE, et al. In vitro hyperglycemia or a diabetic intrauterine environment reduces neonatal endothelial colony forming cell numbers and function. Diabetes. 2008;57:724–731
  40. Javed MJ, Mead LE, Prater D, et al. Endothelial colony forming cells and mesenchymal stem cells are enriched at different gestational ages in human umbilical cord blood. Pediatr Res. 2008;64:68–73
  41. Baker CD, Ryan SL, Ingram DA, et al. Endothelial colony forming cells from preterm infants are increased and more susceptible to hyperoxia. Am J Respir Crit Care Med. 2009;180:454–461
  42. Levine RJ, Maynard SE, Qian C, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004;350:672–683
  43. Wallner W, Sengenberger R, Strick R, et al. Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction. Clin Sci. 2007;112:51–57
  44. Staff AC, Braekke K, Harsem NK, et al. Circulating concentration of sFlt1 in fetal and maternal serum during pre-eclampsia. Eur J Obstet Gynecol Reprod Biol. 2005;22:33–39
  45. Piccin A, Murphy WG, Smith OP. Circulating microparticles: Pathophysiology and clinical implications. Blood Rev. 2007;21:157–171

PII: S0146-0005(10)00016-9

doi: 10.1053/j.semperi.2010.02.002

Seminars in Perinatology
Volume 34, Issue 3 , Pages 188-192 , June 2010

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