Seminars in Perinatology
Volume 34, Issue 1 , Pages 79-86 , February 2010

The Role of Functional Magnetic Resonance Imaging in the Study of Brain Development, Injury, and Recovery in the Newborn

  • Mohamed L. Seghier, PhD

      Affiliations

    • Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom
    • Corresponding Author InformationAddress reprint requests to Mohamed L. Seghier, PhD, Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, 12 Queen Square, London WC1N 3BG, United Kingdom
    • ,
  • Petra S. Hüppi, MD

      Affiliations

    • Division of Child Development and Growth, Department of Pediatrics, Geneva Children's Hospital, Geneva, Switzerland

References 

  1. Ananth CV, Joseph KS, Oyelese Y, et al. Trends in preterm birth and perinatal mortality among singletons: United States, 1989 through 2000. Obstet Gynecol. 2005;105:1084–1091
  2. Larroque B, Ancel PY, Marret S, et al. Neurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study. Lancet. 2008;371:813–820
  3. Zimmerman RA. Pediatric cerebrovascular disease. JBR-BTR. 2000;83:245–252
  4. Panigrahy A, Bluml S. Advances in magnetic resonance neuroimaging techniques in the evaluation of neonatal encephalopathy. Top Magn Reson Imaging. 2007;18:3–29
  5. Price CJ, Friston KJ. Degeneracy and cognitive anatomy. Trends Cogn Sci. 2002;6:416–421
  6. Lazar RM, Antoniello D. Variability in recovery from aphasia. Curr Neurol Neurosci Rep. 2008;8:497–502
  7. Als H, Duffy FH, McAnulty GB, et al. Early experience alters brain function and structure. Pediatrics. 2004;113:846–857
  8. Seyffert M, Castellanos FX. Functional MRI in pediatric neurobehavioral disorders. Int Rev Neurobiol. 2005;67:239–284
  9. Munson S, Schroth E, Ernst M. The role of functional neuroimaging in pediatric brain injury. Pediatrics. 2006;117:1372–1381
  10. Ogawa S, Menon RS, Kim SG, et al. On the characteristics of functional magnetic resonance imaging of the brain. Annu Rev Biophys Biomol Struct. 1998;27:447–474
  11. Logothetis NK, Pfeuffer J. On the nature of the BOLD fMRI contrast mechanism. Magn Reson Imaging. 2004;22:1517–1531
  12. Keri S, Gulyas B. Four facets of a single brain: behaviour, cerebral blood flow/metabolism, neuronal activity and neurotransmitter dynamics. Neuroreport. 2003;14:1097–1106
  13. Logothetis NK, Pauls J, Augath M, et al. Neurophysiological investigation of the basis of the fMRI signal. Nature. 2001;412:150–157
  14. Logothetis NK. What we can do and what we cannot do with fMRI. Nature. 2008;453:869–878
  15. Stokowski LA. Ensuring safety for infants undergoing magnetic resonance imaging. Adv Neonatal Care. 2005;5:14–27
  16. Shellock FG, Crues JV. MR procedures: biologic effects, safety, and patient care. Radiology. 2004;232:635–652
  17. Fenton A, Meynell L, Baylis F. Ethical challenges and interpretive difficulties with non-clinical applications of pediatric FMRI. Am J Bioeth. 2009;9:3–13
  18. Desmond JE, Chen ASH. Ethical issues in the clinical application of fMRI: factors affecting the validity and interpretation of activations. Brain Cogn. 2002;50:482–497
  19. Faro SH, Mohamed FB. Functional MRI: Basic Principles and Clinical Applications. New York, NY: Springer; 2006;
  20. Josephs O, Henson RNA. Event-related functional magnetic resonance imaging: modelling, inference and optimization. Philos Trans R Soc Lond B. 1999;354:1215–1228
  21. Rosen BR, Buckner RL, Dale AM. Event-related functional MRI: past, present, and future. Proc Natl Acad Sci USA. 1998;95:773–780
  22. Matthews PM, Honey GD, Bullmore ET. Applications of fMRI in translational medicine and clinical practice. Nat Rev Neurosci. 2006;7:732–744
  23. Seghier ML, Lazeyras F, Huppi PS. Functional MRI of the newborn. Semin Fetal Neonatal Med. 2006;11:479–488
  24. Wilke M, Holland SK, Myseros JS, et al. Functional magnetic resonance imaging in pediatrics. Neuropediatrics. 2003;34:225–233
  25. Thomas KM, Casey BJ. Functional MRI in pediatrics. In:  Moonen CTW,  Bandettini PA editor. Functional MRI. Berlin, Germany: Springer-Verlag; 1999;p. 513–523
  26. Poldrack RA, Pare-Blagoev EJ, Grant PE. Pediatric functional magnetic resonance imaging: progress and challenges. Top Magn Reson Imaging. 2002;13:61–70
  27. Bookheimer SY. Methodological issues in pediatric neuroimaging. Ment Retard Dev Disabil Res Rev. 2000;6:161–165
  28. Gaillard WD, Grandin CB, Xu B. Developmental aspects of pediatric fMRI: considerations for image acquisition, analysis, and interpretation. Neuroimage. 2001;13:239–249
  29. O'Shaughnessy ES, Berl MM, Moore EN, et al. Pediatric functional magnetic resonance imaging (fMRI): issues and applications. J Child Neurol. 2008;23:791–801
  30. Kotsoni E, Byrd D, Casey BJ. Special considerations for functional magnetic resonance imaging of pediatric populations. J Magn Reson Imaging. 2006;23:877–886
  31. Fujiwara N, Sakatani K, Katayama Y, et al. Evoked-cerebral blood oxygenation changes in false-negative activations in BOLD contrast functional MRI of patients with brain tumors. Neuroimage. 2004;21:1464–1471
  32. Sakatani K, Murata Y, Fujiwara N, et al. Comparison of blood-oxygen-level-dependent functional magnetic resonance imaging and near-infrared spectroscopy recording during functional brain activation in patients with stroke and brain tumors. J Biomed Opt. 2007;12:062110
  33. Bonakdarpour B, Parrish TB, Thompson CK. Hemodynamic response function in patients with stroke-induced aphasia: implications for fMRI data analysis. Neuroimage. 2007;36:322–331
  34. Miller MB, Van Horn JD. Individual variability in brain activations associated with episodic retrieval: a role for large-scale databases. Int J Psychophysiol. 2007;63:205–213
  35. Seghier ML, Lazeyras F, Pegna AJ, et al. Group analysis and the subject factor in functional magnetic resonance imaging: analysis of fifty right-handed healthy subjects in a semantic language task. Hum Brain Mapp. 2008;29:461–477
  36. Loring DW, Meador KJ, Allison JD, et al. Now you see it, now you don't: statistical and methodological considerations in fMRI. Epilepsy Behav. 2002;3:539–547
  37. Genovese CR, Lazar NA, Nichols T. Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage. 2002;15:870–878
  38. Nichols T, Hayasaka S. Controlling the familywise error rate in functional neuroimaging: a comparative review. Stat Methods Med Res. 2003;12:419–446
  39. Born P, Leth H, Miranda MJ, et al. Visual activation in infants and young children studied by functional magnetic resonance imaging. Pediatr Res. 1998;44:578–583
  40. Martin E, Joeri P, Loenneker T, et al. Visual processing in infants and children studied using functional MRI. Pediatr Res. 1999;46:135–140
  41. Yamada H, Sadato N, Konishi Y, et al. A rapid brain metabolic change in infants detected by fMRI. Neuroreport. 1997;8:3775–3778
  42. Muramoto S, Yamada H, Sadato N, et al. Age dependent change in metabolic response to photic stimulation of the primary visual cortex in infants: functional magnetic resonance imaging study. J Comput Assist Tomogr. 2002;26:894–901
  43. Altman NR, Bernal B. Brain activation in sedated children: auditory and visual functional MR imaging. Radiology. 2001;221:56–63
  44. Anderson AW, Marois R, Colson ER, et al. Neonatal auditory activation detected by functional magnetic resonance imaging. Magn Reson Imaging. 2001;19:1–5
  45. Erberich SG, Panigrahy A, Friedlich P, et al. Somatosensory lateralization in the newborn brain. Neuroimage. 2006;29:155–161
  46. Dehaene-Lambertz G, Dehaene S, Hertz-Pannier L. Functional neuroimaging of speech perception in infants. Science. 2002;298:2013–2015
  47. Bernal B, Altman N. Visual functional magnetic resonance imaging in patients with Sturge-Weber syndrome. Pediatr Neurol. 2004;31:9–15
  48. Born AP, Miranda MJ, Rostrup E, et al. Functional magnetic resonance imaging of the normal and abnormal visual system in early life. Neuropediatrics. 2000;31:24–32
  49. Heep A, Scheef L, Jankowski J, et al. Functional magnetic resonance imaging of the sensorimotor system in preterm infants. Pediatrics. 2009;123:294–300
  50. Seghier ML, Lazeyras F, Zimine S, et al. Combination of event-related fMRI and diffusion tensor imaging in an infant with perinatal stroke. Neuroimage. 2004;21:463–472
  51. Seghier ML, Lazeyras F, Zimine S, et al. Visual recovery after perinatal stroke evidenced by functional and diffusion MRI. BMC Neurol. 2005;5:17
  52. Sie LTL, Rombouts SA, Valk IJ, et al. Functional MRI of visual cortex in sedated 18 month-old infants with or without periventricular leukomalacia. Dev Med Child Neurol. 2001;43:486–490
  53. Souweidane MM, Kim KH, McDowall R, et al. Brain mapping in sedated infants and young children with passive-functional magnetic resonance imaging. Pediatr Neurosurg. 1999;30:86–92
  54. Byars AW, Holland SK, Strawsburg RH, et al. Practical aspects of conducting large-scale functional magnetic resonance imaging studies in children. J Child Neurol. 2002;17:885–890
  55. Boyd LA, Vidoni ED, Daly JJ. Answering the call: the influence of neuroimaging and electrophysiological evidence on rehabilitation. Phys Ther. 2007;87:684–703
  56. Redcay E, Haist F, Courchesne F. Functional neuroimaging of speech perception during a pivotal period in language acquisition. Dev Sci. 2008;11:237–252
  57. Fox MD, Raichle ME. Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci. 2007;8:700–711
  58. Raichle ME, Snyder AZ. A default mode of brain function: a brief history of an evolving idea. Neuroimage. 2007;37:1083–1090
  59. Damoiseaux JS, Rombouts SA, Barkhof F, et al. Consistent resting-state networks across healthy subjects. Proc Natl Acad Sci USA. 2006;103:13848–13853
  60. van den Heuvel M, Mandl R, Hulshoff Pol H. Normalized cut group clustering of resting-state fMRI data. PLoS One. 2008;3:e2001
  61. Kiviniemi V, Jauhiainen J, Tervonen O, et al. Slow vasomotor fluctuation in fMRI of anesthetized child brain. Magn Reson Med. 2000;44:373–378
  62. Fransson P, Skiöld B, Horsch S, et al. Resting-state networks in the infant brain. Proc Natl Acad Sci USA. 2007;104:15531–15536
  63. Liu WC, Flax JF, Guise KG, et al. Functional connectivity of the sensorimotor area in naturally sleeping infants. Brain Res. 2008;1223:42–49
  64. Lin W, Zhu Q, Gao W, et al. Functional connectivity MR imaging reveals cortical functional connectivity in the developing brain. AJNR Am J Neuroradiol. 2008;29:1883–1889
  65. Fransson P, Skiöld B, Engström M, et al: Spontaneous brain activity in the newborn brain during natural sleep—an fMRI study in infants born at full term. Pediatr Res (in press)
  66. Kiviniemi V. Endogenous brain fluctuations and diagnostic imaging. Hum Brain Mapp. 2008;29:810–817
  67. Garrity AG, Pearlson GD, McKiernan K, et al. Aberrant “default mode” functional connectivity in schizophrenia. Am J Psychiatry. 2007;164:450–457
  68. Bluhm RL, Miller J, Lanius RA, et al. Spontaneous low-frequency fluctuations in the BOLD signal in schizophrenic patients: anomalies in the default network. Schizophr Bull. 2007;33:1004–1012
  69. He Y, Wang L, Zang Y, et al. Regional coherence changes in the early stages of Alzheimer's disease: a combined structural and resting-state functional MRI study. Neuroimage. 2007;35:488–500
  70. Tian L, Jiang T, Liang M, et al. Enhanced resting-state brain activities in ADHD patients: a fMRI study. Brain Dev. 2008;30:342–348
  71. Zhu CZ, Zang YF, Liang M, et al. Discriminative analysis of brain function at resting-state for attention-deficit/hyperactivity disorder. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2005;8:468–475
  72. Anand A, Li Y, Wang Y, et al. Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression. Psychiatry Res. 2009;171:189–198
  73. Lowe MJ, Phillips MD, Lurito JT, et al. Multiple sclerosis: low-frequency temporal blood oxygen level-dependent fluctuations indicate reduced functional connectivity initial results. Radiology. 2002;224:184–192
  74. Wang L, Zhu C, He Y, et al. Altered small-world brain functional networks in children with attention-deficit/hyperactivity disorder. Hum Brain Mapp. 2009;30:638–649
  75. Church JA, Fair DA, Dosenbach NU, et al. Control networks in paediatric Tourette syndrome show immature and anomalous patterns of functional connectivity. Brain. 2009;132:225–238
  76. Fair DA, Schlaggar BL, Cohen AL, et al. A method for using blocked and event-related fMRI data to study “resting state” functional connectivity. Neuroimage. 2007;35:396–405
  77. Sporns O. Brain connectivity. Scholarpedia J. 2007;2:4695
  78. Huppi PS, Dubois J. Diffusion tensor imaging of brain development. Semin Fetal Neonatal Med. 2006;11:489–497
  79. McIntosh AR, Gonzalez-Lima F. Structural equation modeling and its application to network analysis in functional brain imaging. Hum Brain Mapp. 1994;2:2–22
  80. Friston KJ, Harrison L, Penny W. Dynamic causal modelling. Neuroimage. 2003;19:1273–1302
  81. Roebroeck A, Formisano E, Goebel R. Mapping directed influence over the brain using Granger causality and fMRI. Neuroimage. 2005;25:230–242
  82. Abutalebi J, Rosa PA, Tettamanti M, et al. Bilingual aphasia and language control: a follow-up fMRI and intrinsic connectivity study. Brain Lang. 2009;109:141–156
  83. Sonty SP, Mesulam MM, Weintraub S, et al. Altered effective connectivity within the language network in primary progressive aphasia. J Neurosci. 2007;27:1334–1345
  84. Cao F, Bitan T, Booth JR. Effective brain connectivity in children with reading difficulties during phonological processing. Brain Lang. 2008;107:91–101
  85. Richter W, Richter M. The shape of the fMRI BOLD response in children and adults changes systematically with age. Neuroimage. 2003;20:1122–1131
  86. Binkofski F, Seitz R. Modulation of the BOLD-response in early recovery from sensorimotor stroke. Neurology. 2004;63:1223–1229
  87. Martin E, Thiel T, Joeri P, et al. Effect of pentobarbital on visual processing in man. Hum Brain Mapp. 2000;10:132–139
  88. Fernandez B, Cardebat D, Demonet JF, et al. Functional MRI follow-up of language processes in healthy subjects and during recovery in a case of aphasia. Stroke. 2004;35:2171–2176
  89. Seghier ML, Friston KJ, Price CJ. Detecting subject-specific activations using fuzzy clustering. Neuroimage. 2007;36:594–605
  90. Redcay E, Courchesne F. Deviant functional magnetic resonance imaging patterns of brain activity to speech in 2-3-year-old children with autism spectrum disorder. Biol Psychiatry. 2008;64:589–598
  91. Tracey I, Wise RG. Pharmacological fMRI: a new tool for drug development in humans. J Pharm Practice. 2001;14:368–375

PII: S0146-0005(09)00096-2

doi: 10.1053/j.semperi.2009.10.008

Seminars in Perinatology
Volume 34, Issue 1 , Pages 79-86 , February 2010

Article Tools

* Image Usage & Resolution