Seminars in Perinatology
Volume 34, Issue 1 , Pages 39-45 , February 2010

Applications of Positron Emission Tomography in the Newborn Nursery

  • Sujatha Kannan, MD

      Affiliations

    • Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI
  • ,
  • Harry T. Chugani, MD

      Affiliations

    • Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI
    • Department of Neurology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI
    • The PET Center, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI
    • Corresponding Author InformationAddress reprint requests to Harry T. Chugani, MD, Division of Pediatric Neurology, Children's Hospital of Michigan, 3901 Beaubien Blvd., Detroit, MI 48201

References 

  1. Chugani HT, Phelps ME. Maturational changes in cerebral function in infants determined by 18FDG positron emission tomography. Science. 1986;231:840–843
  2. Chugani HT, Phelps ME, Mazziotta JC. Positron emission tomography study of human brain functional development. Ann Neurol. 1987;22:487–497
  3. Chugani HT. A critical period of brain development: studies of cerebral glucose utilization with PET. Prev Med. 1998;27:184–188
  4. Kinnala A, Suhonen-Polvi H, Aärimaa T, et al. Cerebral metabolic rate for glucose during the first six months of life: an FDG positron emission tomography study. Arch Dis Child Fetal Neonatal Ed. 1996;74:F153–F157
  5. Chugani HT, Behen ME, Muzik O, et al. Local brain functional activity following early deprivation: a study of postinstitutionalized Romanian orphans. Neuroimage. 2001;14:1290–1301
  6. Berg AT, Levy SR, Novotny EJ, et al. Predictors of intractable epilepsy in childhood: a case-control study. Epilepsia. 1996;37:24–30
  7. Sun Y, Vestergaard M, Christensen J, et al. Prenatal exposure to maternal infections and epilepsy in childhood: a population-based cohort study. Pediatrics. 2008;121:e1100–e1107
  8. Whitehead E, Dodds L, Joseph KS, et al. Relation of pregnancy and neonatal factors to subsequent development of childhood epilepsy: a population-based cohort study. Pediatrics. 2006;117:1298–1306
  9. Thibeault-Eybalin MP, Lortie A, Carmant L. Neonatal seizures: Do they damage the brain?. Pediatr Neurol. 2009;40:175–180
  10. Juhász C, Chugani HT. Imaging the epileptic brain with positron emission tomography (Review). Neuroimag Clin N Am. 2003;13:705–716viii
  11. Chugani HT. The role of PET in childhood epilepsy. J Child Neurol. 1994;9(suppl 1):S82–S88
  12. Da Silva EA, Chugani DC, Muzik O, et al. Identification of frontal lobe epileptic foci in children using positron emission tomography. Epilepsia. 1997;38:1198–1208
  13. Juhász C, Chugani DC, Muzik O, et al. Relationship of flumazenil and glucose PET abnormalities to neocortical epilepsy surgery outcome. Neurology. 2001;26:1650–1658
  14. Savic I, Thorell JO, Roland P. [11C]Flumazenil positron emission tomography visualizes frontal epileptogenic regions. Epilepsia. 1996;36:1225–1232
  15. Muzik O, da Silva EA, Juhasz C, et al. Intracranial EEG versus flumazenil and glucose PET in children with extratemporal lobe epilepsy. Neurology. 2000;11:171–179
  16. Juhász C, Chugani DC, Muzik O. Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy. Neurology. 2003;25:960–968
  17. Juhász C, Chugani DC, Muzik O, et al. Relationship between EEG and positron emission tomography abnormalities in clinical epilepsy. J Clin Neurophysiol. 2000;17:29–42
  18. Asano E, Chugani DC, Juhász C, et al. Surgical treatment of West syndrome. Brain Dev. 2001;23:668–676
  19. Koman LA, Smith BP, Shilt JS. Cerebral palsy. Lancet. 2004;363:1619–1631
  20. Bejar RF, Vaucher YE, Benirschke K, et al. Postnatal white matter necrosis in preterm infants. J Perinatol. 1992;12:3–8
  21. Cioni G, Di Paco MC, Bertuccelli B, et al. MRI findings and sensorimotor development in infants with bilateral spastic cerebral palsy. Brain Dev. 1997;19:245–253
  22. Hashimoto K, Hasegawa H, Kida Y, et al. Correlation between neuroimaging and neurological outcome in periventricular leukomalacia: diagnostic criteria. Pediatr Int. 2001;43:240–245
  23. Kułak W, Sobaniec W, Kubas B, et al. Spastic cerebral palsy: clinical magnetic resonance imaging correlation of 129 children. J Child Neurol. 2007;22:8–14
  24. Lee ZI, Byun WM, Jang SH, et al. Diffusion tensor magnetic resonance imaging of microstructural abnormalities in children with brain injury. Am J Phys Med Rehabil. 2003;82:556–559
  25. Son SM, Ahn YH, Sakong J, et al. Diffusion tensor imaging demonstrates focal lesions of the corticospinal tract in hemiparetic patients with cerebral palsy. Neurosci Lett. 2007;420:34–38
  26. Korzeniewski SJ, Birbeck G, DeLano MC, et al. A systematic review of neuroimaging for cerebral palsy. J Child Neurol. 2008;23:216–227
  27. Volpe JJ, Herscovitch P, Perlman JM, et al. Positron emission tomography in the newborn: extensive impairment of regional cerebral blood flow with intraventricular hemorrhage and hemorrhagic intracerebral involvement. Pediatrics. 1983;72:589–601
  28. Volpe JJ, Herscovitch P, Perlman JM, et al. Positron emission tomography in the asphyxiated term newborn: parasagittal impairment of cerebral blood flow. Ann Neurol. 1985;17:287–296
  29. Altman DI, Volpe JJ. Positron emission tomography in newborn infants (Review). Clin Perinatol. 1991;18:549–562
  30. Kerrigan JF, Chugani HT, Phelps ME. Regional cerebral glucose metabolism in clinical subtypes of cerebral palsy. Pediatr Neurol. 1991;7:415–425
  31. Inder TE, Huppi PS, Warfield S, et al. Periventricular white matter injury in the premature infant is followed by reduced cerebral cortical gray matter volume at term. Ann Neurol. 1999;46:755–760
  32. Batista CE, Chugani HT, Juhász C, et al. Transient hypermetabolism of the basal ganglia following perinatal hypoxia. Pediatr Neurol. 2007;36:330–333
  33. Hoon AH, Lawrie WT, Melhem ER, et al. Diffusion tensor imaging of periventricular leukomalacia shows affected sensory cortex white matter pathways. Neurology. 2002;10:752–756
  34. Lee JD, Park HJ, Park ES, et al. Assessment of regional GABA(A) receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy. Neuroimage. 2007;34:19–25
  35. Chugani DC, Muzik O, Juhász C, et al. Postnatal maturation of human GABAA receptors measured with positron emission tomography. Ann Neurol. 2001;49:618–626
  36. Bell MJ, Hallenbeck JM. Effects of intrauterine inflammation on developing rat brain. J Neurosci Res. 2002;70:570–579
  37. Cai Z, Pan ZL, Pang Y, et al. Cytokine induction in fetal rat brains and brain injury in neonatal rats after maternal lipopolysaccharide administration. Pediatr Res. 2000;47:64–72
  38. Saadani-Makki F, Kannan S, Lu X, et al. Intrauterine administration of endotoxin leads to motor deficits in a rabbit model: a link between prenatal infection and cerebral palsy. Am J Obstet Gynecol. 2008;199:651–657
  39. Li J, Baud O, Vartanian T, et al. Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes. Proc Natl Acad Sci USA. 2005;102:9936–9941
  40. Block ML, Zecca L, Hong JS. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci. 2007;8:57–69
  41. Vilhardt F. Microglia: phagocyte and glia cell. Int J Biochem Cell Biol. 2005;37:17–21
  42. Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science. 2005;308:1314–1318
  43. Billiards SS, Haynes RL, Folkerth RD, et al. Development of microglia in the cerebral white matter of the human fetus and infant. J Comp Neurol. 2006;497:199–208
  44. Lawson LJ, Perry VH, Dri P, et al. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience. 1990;39:151–170
  45. Haynes RL, Folkerth RD, Keefe RJ, et al. Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia. J Neuropathol Exp Neurol. 2003;62:441–450
  46. Espey MG, Chernyshev ON, Reinhard JF, et al. Activated human microglia produce the excitotoxin quinolinic acid. Neuroreport. 1997;8:431–434
  47. Dommergues MA, Plaisant F, Verney C, et al. Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection. Neuroscience. 2003;121:619–628
  48. Fern R, Moller T. Rapid ischemic cell death in immature oligodendrocytes: a fatal glutamate release feedback loop. J Neurosci. 2000;20:34–42
  49. Salter MG, Fern R. NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury. Nature. 2005;438:1167–1171
  50. Dammann O, Leviton A. Infection remote from the brain, neonatal white matter damage, and cerebral palsy in the preterm infant. Semin Pediatr Neurol. 1998;5:190–201
  51. Nelson KB, Dambrosia JM, Grether JK, et al. Neonatal cytokines and coagulation factors in children with cerebral palsy. Ann Neurol. 1998;44:665–675
  52. Yoon BH, Romero R, Park JS, et al. Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obstet Gynecol. 2000;182:675–681
  53. Hailer NP, Vogt C, Korf HW, et al. Interleukin-1beta exacerbates and interleukin-1 receptor antagonist attenuates neuronal injury and microglial activation after excitotoxic damage in organotypic hippocampal slice cultures. Eur J Neurosci. 2005;21:2347–2360
  54. Lehnardt S, Lachance C, Patrizi S, et al. The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci. 2002;22:2478–2486
  55. Garnier M, Boujrad N, Ogwuegbu SO, et al. The polypeptide diazepam-binding inhibitor and a higher affinity mitochondrial peripheral-type benzodiazepine receptor sustain constitutive steroidogenesis in the R2C Leydig tumor cell line. J Biol Chem. 1994;269:22105–22112
  56. Banati RB. Visualising microglial activation in vivo. Glia. 2002;40:206–217
  57. Gerhard A, Banati RB, Goerres GB, et al. [11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy. Neurology. 2003;61:686–689
  58. Papadopoulos V, Baraldi M, Guilarte TR, et al. Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci. 2006;27:402–409
  59. Gerhard A, Pavese N, Hotton G, et al. In vivo imaging of microglial activation with [11C] (R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiol Dis. 2006;21:404–412
  60. Kannan S, Saadani-Makki F, Muzik O, et al. Microglial activation in perinatal rabbit brain induced by intrauterine inflammation: detection with 11C-(R)-PK11195 and small-animal PET. J Nucl Med. 2007;48:946–954
  61. Brenner DJ, Hall EJ. Computed tomography—an increasing source of radiation exposure. N Engl J Med. 2007;357:2277–2284

PII: S0146-0005(09)00092-5

doi: 10.1053/j.semperi.2009.10.004

Seminars in Perinatology
Volume 34, Issue 1 , Pages 39-45 , February 2010