Seminars in Perinatology
Volume 34, Issue 1 , Pages 20-27 , February 2010

Magnetic Resonance Spectroscopy Imaging of the Newborn Brain—A Technical Review

  • Duan Xu, PhD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Duan Xu, PhD, Department of Radiology and Biomedical Imaging, Joint UCSF/UC Berkeley Graduate Group in Bioengineering, University of California, San Francisco, 1700 4th St, Byers Hall, Suite 102, San Francisco, CA 94158
  • ,
  • Daniel Vigneron, PhD

References 

  1. Smith FW. The value of NMR imaging in pediatric practice—a preliminary report. Pediatr Radiol. 1983;13:141–147
  2. Johnson MA, Pennock JM, Bydder GM, et al. Clinical NMR imaging of the brain in children—normal and neurologic disease. AJNR Am J Neuroradiol. 1983;4:1013–1026
  3. Partridge SC, Mukherjee P, Henry RG, et al. Diffusion tensor imaging: serial quantitation of white matter tract maturity in premature newborns. Neuroimage. 2004;22:1302–1314
  4. Ketonen LM, Valanne L. Neuroimaging of pediatric diseases. Semin Neurol. 2008;28:558–569
  5. Barkovich AJ, Westmark KD, Bedi HS, et al. Proton spectroscopy and diffusion imaging on the first day of life after perinatal asphyxia: preliminary report. AJNR Am J Neuroradiol. 2001;22:1786–1794
  6. Barkovich AJ, Miller SP, Bartha A, et al. MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy. AJNR Am J Neuroradiol. 2006;27:533–547
  7. Huppi PS, Lazeyras F. Proton magnetic resonance spectroscopy ((1)H-MRS) in neonatal brain injury. Pediatr Res. 2001;49:317–320
  8. Huppi PS, Dubois J. Diffusion tensor imaging of brain development. Semin Fetal Neonatal Med. 2006;11:489–497
  9. Miller SP, McQuillen PS, Hamrick S, et al. Abnormal brain development in newborns with congenital heart disease. N Engl J Med. 2007;357:1928–1938
  10. Barkovich AJ, Baranski K, Vigneron D, et al. Proton MR spectroscopy for the evaluation of brain injury in asphyxiated, term neonates. AJNR Am J Neuroradiol. 1999;20:1399–1405
  11. Peden CJ, Cowan FM, Bryant DJ, et al. Proton MR spectroscopy of the brain in infants. J Comput Assist Tomogr. 1990;14:886–894
  12. Hwang JH, Egnaczyk GF, Ballard E, et al. Proton MR spectroscopic characteristics of pediatric pilocytic astrocytomas. AJNR Am J Neuroradiol. 1998;19:535–540
  13. Bloch F. Nuclear induction. Phys Rev. 1946;70:460–474
  14. Bottomley PA. Spatial localization in NMR spectroscopy in vivo. Ann NY Acad Sci. 1987;508:333–348
  15. Frahm J, Merboldt KD, Hanicke W. Localized proton spectroscopy using stimulated echoes. J Magn Reson. 1987;72:502–508
  16. Nelson SJ. Analysis of volume MRI and MR spectroscopic imaging data for the evaluation of patients with brain tumors. Magn Reson Med. 2001;46:228–239
  17. Hajnal JV, Saeed N, Soar EJ, et al. A registration and interpolation procedure for Subvoxel matching of serially acquired MR images. J Comput Assist Tomogr. 1995;19:289–296
  18. Nelson SJ. Multivoxel magnetic resonance spectroscopy of brain tumors. Mol Cancer Ther. 2003;2:497–507
  19. Mescher M, Merkle H, Kirsch J, et al. Simultaneous in vivo spectral editing and water suppression. NMR Biomed. 1998;11:266–272
  20. Star-Lack J, Nelson SJ, Kurhanewicz J, et al. Improved water and lipid suppression for 3D PRESS CSI using RF band selective inversion with gradient dephasing (BASING). Magn Reson Med. 1997;38:311–321
  21. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med. 1993;30:672–679
  22. Pels P, Ozturk-Isik E, Swanson MG, et al. Quantification of prostate MRSI data by model-based time domain fitting and frequency domain analysis. NMR Biomed. 2006;19:188–197
  23. Van Huffel S, Wang Y, Vanhamme L, et al. Automatic frequency alignment and quantitation of single resonances in multiple magnetic resonance spectra via complex principal component analysis. J Magn Reson. 2002;158:1–14
  24. Kimura H, Fujii Y, Itoh S, et al. Metabolic alterations in the neonate and infant brain during development—evaluation with proton MR spectroscopy. Radiology. 1995;194:483–489
  25. Vigneron DB, Barkovich AJ, Noworolski SM, et al. Three-dimensional proton MR spectroscopic imaging of premature and term neonates. AJNR Am J Neuroradiol. 2001;22:1424–1433
  26. Kreis R, Hofmann L, Kuhlmann B, et al. Brain metabolite composition during early human brain development as measured by quantitative in vivo 1H magnetic resonance spectroscopy. Magn Reson Med. 2002;48:949–958
  27. Kreis R, Ernst T, Ross BD. Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. Magn Reson Med. 1993;30:424–437
  28. Kantarci K, Petersen RC, Boeve BF, et al. H-1 MR spectroscopy in common dementias. Neurology. 2004;63:1393–1398
  29. Barkovich AJ. Normal development. In: Pediatric Neuroimaging. Philadelphia, PA: Lippincott Williams & Wilkins; 2000;p. 13–69
  30. Haseler LJ, Arcinue E, Danielsen ER, et al. Evidence from proton magnetic resonance spectroscopy for a metabolic cascade of neuronal damage in shaken baby syndrome. Pediatrics. 1997;99:4–14
  31. Ross BD, Ernst T, Kreis R, et al. 1H MRS in acute traumatic brain injury. J Magn Reson Imaging. 1998;8:829–840
  32. Makoroff KL, Cecil KM, Care M, et al. Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury. Pediatr Radiol. 2005;35:668–676
  33. Boddaert N, Romano S, Funalot B, et al. 1H MRS spectroscopy evidence of cerebellar high lactate in mitochondrial respiratory chain deficiency. Mol Genet Metab. 2008;93:85–88
  34. Fan G, Wu Z, Chen L, et al. Hypoxia-ischemic encephalopathy in full-term neonate: correlation proton MR spectroscopy with MR imaging. Eur J Radiol. 2003;45:91–98
  35. Zarifi MK, Astrakas LG, Poussaint TY, et al. Prediction of adverse outcome with cerebral lactate level and apparent diffusion coefficient in infants with perinatal asphyxia. Radiology. 2002;225:859–870
  36. Zhu W, Zhong W, Qi J, et al. Proton magnetic resonance spectroscopy in neonates with hypoxic-ischemic injury and its prognostic value. Transl Res. 2008;152:225–232
  37. Ashwal S, Holshouser B, Tong K, et al. Proton spectroscopy detected myoinositol in children with traumatic brain injury. Pediatr Res. 2004;56:630–638
  38. Holshouser BA, Ashwal S, Shu S, et al. Proton MR spectroscopy in children with acute brain injury: comparison of short and long echo time acquisitions. J Magn Reson Imaging. 2000;11:9–19
  39. Dydak U, Weiger M, Pruessmann KP, et al. Sensitivity-encoded spectroscopic imaging. Magn Reson Med. 2001;46:713–722
  40. Ozturk E, Banerjee S, Majumdar S, et al. Partially parallel MR spectroscopic imaging of gliomas at 3T. Conf Proc IEEE Engl Med Biol Soc. 2006;1:493–496
  41. Cunningham CH, Vigneron DB, Chen AP, et al. Design of flyback echo-planar readout gradients for magnetic resonance spectroscopic imaging. Magn Reson Med. 2005;54:1286–1289
  42. Kim DH, Gu M, Spielman DM. Gradient moment compensated magnetic resonance spectroscopic imaging. Magn Reson Med. 2009;61:457–461
  43. Kim DH, Gu M, Cunningham C, et al. Fast 3D 1H MRSI of the corticospinal tract in pediatric brain. J Magn Reson Imaging. 2009;29:1–6
  44. Mayer D, Kim DH, Spielman DM, et al. Fast parallel spiral chemical shift imaging at 3T using iterative SENSE reconstruction. Magn Reson Med. 2008;59:891–897
  45. Posse S, Otazo R, Tsai SY, et al. Single-shot magnetic resonance spectroscopic imaging with partial parallel imaging. Magn Reson Med. 2009;61:541–547
  46. Chen AP, Cunningham CH, Ozturk-Isik E, et al. High-speed 3T MR spectroscopic imaging of prostate with flyback echo-planar encoding. J Magn Reson Imaging. 2007;25:1288–1292
  47. Hurd R, Sailasuta N, Srinivasan R, et al. Measurement of brain glutamate using TE-averaged PRESS at 3T. Magn Reson Med. 2004;51:435–440
  48. Dreher W, Leibfritz D. Detection of homonuclear decoupled in vivo proton NMR spectra using constant time chemical shift encoding: CT-PRESS. Magn Reson Imaging. 1999;17:141–150
  49. Li Y, Chen AP, Crane JC, et al. Three-dimensional J-resolved H-1 magnetic resonance spectroscopic imaging of volunteers and patients with brain tumors at 3T. Magn Reson Med. 2007;58:886–892
  50. Mayer D, Spielman DM. Detection of glutamate in the human brain at 3T using optimized constant time point resolved spectroscopy. Magn Reson Med. 2005;54:439–442

 This work is partially supported by NIH grants 5P50NS035902, 1R01NS046432, and 1R01EB009756.

PII: S0146-0005(09)00091-3

doi: 10.1053/j.semperi.2009.10.003

Seminars in Perinatology
Volume 34, Issue 1 , Pages 20-27 , February 2010