Seminars in Perinatology
Volume 34, Issue 1 , Pages 20-27, February 2010

Magnetic Resonance Spectroscopy Imaging of the Newborn Brain—A Technical Review

  • Duan Xu, PhD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Duan Xu, PhD, Department of Radiology and Biomedical Imaging, Joint UCSF/UC Berkeley Graduate Group in Bioengineering, University of California, San Francisco, 1700 4th St, Byers Hall, Suite 102, San Francisco, CA 94158
    • ,
  • Daniel Vigneron, PhD

Department of Radiology and Biomedical Imaging, Joint UCSF/UC Berkeley Graduate Group in Bioengineering, University of California, San Francisco, CA

Magnetic resonance imaging has been widely used noninvasively for pediatric neuroimaging for more than a decade. More recently, with advances in computing, functional techniques for imaging water diffusion, cellular metabolite levels, and blood flow are becoming available. Magnetic resonance spectroscopy imaging (MRSI) offers a snapshot of the metabolic status in the tissue of interest. It is complementary to the more traditionally used anatomic imaging for diagnoses of various abnormalities. This review describes the physical basis of proton MRSI, summarizes currently available techniques and their applications, highlights challenges of performing MRSI in the pediatric population, and previews the newest techniques currently on the horizon.

Keywords: newborn, brain, spectroscopy, MRSI

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 This work is partially supported by NIH grants 5P50NS035902, 1R01NS046432, and 1R01EB009756.

PII: S0146-0005(09)00091-3

doi:10.1053/j.semperi.2009.10.003

Seminars in Perinatology
Volume 34, Issue 1 , Pages 20-27, February 2010

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