Seminars in Perinatology
Volume 34, Issue 1 , Pages 3-19, February 2010

Basic Principles and Concepts Underlying Recent Advances in Magnetic Resonance Imaging of the Developing Brain

  • Ashok Panigrahy, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Ashok Panigrahy, MD, Department of Radiology, Children's Hospital Los Angeles, 4650 Sunset Boulevard, Mail Stop 81, Los Angeles, CA 90027
    • ,
  • Matthew Borzage, MSc
    • ,
  • Stefan Blüml, PhD

Division of Neuroradiology, Department of Radiology, Institute for Maternal Fetal Health, Children's Hospital Los Angeles, University of Southern California School of Medicine, Los Angeles, CA

Over the last decade, magnetic resonance (MR) imaging has become an essential tool in the evaluation of both in vivo human brain development and perinatal brain injury. Recent technology including MR-compatible neonatal incubators, neonatal head coils, advanced MR pulse sequences, and 3-T field strength magnets allow high-quality MR imaging studies to be performed on sick neonates. This article will review basic principles and concepts underlying recent advances in MR spectroscopy, diffusion, perfusion, and volumetric MR imaging. These techniques provide quantitative assessment and novel insight of both brain development and brain injury in the immature brain. Knowledge of normal developmental changes in quantitative MR values is also essential to interpret pathologic cases.

Keywords: blood oxygenation level dependent, diffusion tensor imaging, magnetic resonance imaging, near infrared spectroscopy, periventricular leukomalacia

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 Supported by NIH NS063371-01A1, Radiological Society of North American and Rudi Schulte Research Institute, and NIH pediatric research loan repayment grant.

PII: S0146-0005(09)00089-5

doi:10.1053/j.semperi.2009.10.001

Seminars in Perinatology
Volume 34, Issue 1 , Pages 3-19, February 2010

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