Seminars in Perinatology
Volume 32, Issue 5 , Pages 355-366 , October 2008

Consequences of Neonatal Resuscitation with Supplemental Oxygen

  • Richard J. Martin, MD

      Affiliations

    • Division of Neonatology, Rainbow Babies & Children's Hospital, Cleveland, OH
    • ,
  • G. Bradley Bookatz, Medical Student

      Affiliations

    • Division of Neonatology, Rainbow Babies & Children's Hospital, Cleveland, OH
    • ,
  • Steven L. Gelfand, MD

      Affiliations

    • Division of Neonatology, Rainbow Babies & Children's Hospital, Cleveland, OH
    • ,
  • Juan Sastre, PhD

      Affiliations

    • Department of Pharmacology, University of Valencia, Valencia, Spain
    • ,
  • Alessandro Arduini, PhD Student

      Affiliations

    • Department of Pharmacology, University of Valencia, Valencia, Spain
    • ,
  • Marta Aguar, MD

      Affiliations

    • Neonatal Research Unit, Servicio de Neonatología, Hospital La Fe, Valencia, Spain
    • ,
  • Raquel Escrig, MD

      Affiliations

    • Neonatal Research Unit, Servicio de Neonatología, Hospital La Fe, Valencia, Spain
    • ,
  • Máximo Vento, PhD, MD

      Affiliations

    • Neonatal Research Unit, Servicio de Neonatología, Hospital La Fe, Valencia, Spain
    • Corresponding Author InformationAddress reprint requests to Máximo Vento, PhD, MD, Neonatal Research Unit, Servicio de Neonatología, Hospital Universitario La Fe, Avenida de Campanar, 21, E46009 Valencia, Spain

References 

  1. American Academy of Pediatrics, American Heart Association. Use of resuscitation devices for positive pressure ventilation. In: Textbook of Neonatal Resuscitation. ed 5. Elk Grove Village, IL: American Academy of Pediatrics; 2006;p. 3–14
  2. Saugstad OD, Rootwelt T, Aalen O, et al. Resuscitation of asphyxiated newborn infants with room air or oxygen: an international controlled study. Pediatrics. 1998;102:e1
  3. Vento M, Asensi M, Sastre J, et al. Resuscitation with room air instead of 100% oxygen prevents oxidative stress in moderately asphyxiated term neonates. Pediatrics. 2001;107:642–647
  4. Solberg R, Andresen JH, Escrig R, et al. Resuscitation of hypoxic newborn piglets with oxygen induces a dose-dependent increase in markers of oxidation. Pediatr Res. 2007;62:559–563
  5. Martin RJ, Walsh MC, Carlo WA. Reevaluating neonatal resuscitation with 100% oxygen. Am J Respir Crit Care Med. 2005;172:1393–1398
  6. Kondo M, Itoh S, Isobe K, et al. Chemiluminescence because of the production of reactive oxygen species in the lungs of newborn piglets during resuscitation periods after asphyxiation loads. Pediatr Res. 2000;47:524–537
  7. Munkeby BH, Børke WB, Bjørnland K, et al. Resuscitation with 100% O2 increases cerebral injury in hypoxemic piglets. Pediatr Res. 2004;56:783–790
  8. Bookatz GB, Mayer CA, Wilson CG, et al. Effect of supplemental oxygen on reinitiation of breathing after neonatal resuscitation in rat pups. Pediatr Res. 2007;61:698–702
  9. Rigatto H. Control of breathing in fetal life and onset and control of breathing in the neonate. In:  Polin RA,  Fox WW,  Abman SH editor. Fetal and Neonatal Physiology. Philadelphia, PA: Saunders; 2004;p. 890–900
  10. Dejours P. Control of respiration by arterial chemoreceptors. Ann N Y Acad Sci. 1963;109:682–695
  11. Bouferrache B, Filtchev S, Leke A, et al. The hyperoxic test in infants revisited. Am J Respir Crit Care Med. 2000;161:160–165
  12. Hertzberg T, Hellström S, Holgert H, et al. Ventilatory response to hyperoxia in newborn rats born in hypoxia: possible relationship to carotid body dopamine. J Physiol. 1992;456:645–654
  13. Vannucci RC, Connor JR, Mauger DT, et al. Rat model of perinatal hypoxic-ischemic brain damage. J Neurosci Res. 1999;55:158–163
  14. Presti AL, Kishkurno SV, Slinko SK, et al. Reoxygenation with 100% oxygen versus room air: late neuroanatomical and neurofunctional outcome in neonatal mice with hypoxic-ischemic brain injury. Pediatr Res. 2006;60:55–59
  15. Gelfand SL, Vento M, Sastre J, et al. A new model of hypoxia-induced oxidative stress in rat pups. Neonatology. 2007;(in press)
  16. Lust WD, Feussner GK, Barbehenn EK, et al. The enzymatic measurement of adenine nucleotides and P-creatine in picomole amounts. Anal Biochem. 1981;110:258–266
  17. Fariss MW, Reed DJ. High-performance liquid chromatography of thiols and disulfides: dinitrophenol derivatives. Methods Enzymol. 1987;143:101–109
  18. Asensi M, Sastre J, Pallardo FV, et al. Ratio of reduced to oxidized glutathione as indicator of oxidative stress status and DNA damage. Methods Enzymol. 1999;299:267–276
  19. Wu G, Fang YZ, Yang S, et al. Glutathione metabolism and its implications in health. J Nutr. 2004;134:489–492
  20. Mansfield KD, Simon CM, Keith B. Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species. J Appl Physiol. 2004;97:1358–1366
  21. Romijn HJ, Hofman MA, Gramsbergen A. At what age is the developing cerebral cortex of the rat comparable to that of the full-term newborn human baby?. Early Hum Dev. 1991;26:61–67
  22. Stiller R, von Mering R, König V, et al. How well does reflectance pulse oximetry reflect intrapartum fetal acidosis?. Am J Obstet Gynecol. 2002;186:1351–1357
  23. Kamlin CO, O'Donnell CP, Davis PG, et al. Oxygen saturation in healthy infants immediately after birth. J Pediatr. 2006;148:585–589
  24. Mariani G, Dik PB, Ezquer A, et al. Pre-ductal and post-ductal O2 saturation in healthy term neonates after birth. J Pediatr. 2007;150:418–421
  25. Martin JA, Pereda J, Martinez-López I, et al. Oxidative stress as a signal to up-regulate gamma-cystathionase in the fetal-to-neonatal transition. Cell Mol Biol. 2007;53:OL1010–OL1017
  26. Pallardo FV, Sastre J, Asensi M, et al. Phsyiological changes in glutathione metabolism in foetal and newborn rat liver. Biochem J. 1991;274:891–893
  27. Sastre J, Asensi M, Rodrigo F, et al. Antioxidant administration to the mother prevents oxidative stress associated with birth in the neonatal rat. Life Sci. 1994;54:2055–2059
  28. Li C, Jackson RM. Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am J Physiol Cell Physiol. 2002;282:C227–C241
  29. Saugstad OD. Resuscitation with room air or oxygen supplementation. Clin Perinatol. 1998;25:741–756
  30. Vento M, Asensi M, Sastre J, et al. Hyperoxemia caused by resuscitation with pure oxygen may alter intracelular redox status by increasing oxidized glutathione in asphyxiated newly born infants. Semin Perinatol. 2002;26:406–410
  31. Santore MT, McClintock DS, Lee VY, et al. Anoxia-induced apoptosis occurs through a mitochondria-dependent pathway in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2002;282:L727–L734
  32. Rabi Y, Rabi D, Yee W. Room air resuscitation of the depressed newborn: a systematic review and meta-analysis. Resuscitation. 2007;72:353–363
  33. Wang CL, Anderson C, Leone TA, et al. Resuscitation of preterm neonates using room air or 100% oxygen. Pediatrics. 2008;121:1083–1089
  34. Escrig R, Arruza L, Izquierdo I, et al. Achievement of a targeted saturation in extremely low gestational age neonates resuscitated with low or high oxygen concentrations: a prospective randomized trial. Pediatrics. 2008;(in press)
  35. Vento M, Asensi M, Sastre J, et al. Six years of experience with the use of room air for the resuscitation of asphyxiated newly born term infants. Biol Neonate. 2001;79:261–267
  36. Vento M, Asensi M, Sastre J, et al. Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen. J Pediatr. 2003;142:240–246
  37. Vento M, Sastre J, Asensi MA, et al. Room-air resuscitation causes less damage to heart and kidney than 100% oxygen. Am J Respir Crit Care Med. 2005;172:1393–1398
  38. Ramji S, Rasaily R, Mishra PK, et al. Resuscitation of asphyxiated newborns with room air or 100% oxygen at birth: a multicentric clinical trial. Indian Pediatr. 2003;40:510–517
  39. Bajaj N, Udani RH, Nanavati RN. Room air vs. 100 per cent oxygen for neonatal resuscitation: a controlled clinical trial. J Trop Pediatr. 2005;51:206–211
  40. Nattie E. Why do we have both peripheral and central chemoreceptors?. J Appl Physiol. 2006;100:9–10
  41. Saugstad OD, Ramji S, Rootwelt T, et al. Response to resuscitation of the newborn: early prognostic variables. Acta Paediatr. 2005;94:890–895
  42. Davis PG, Tan A, O'Donnell CP, et al. Resuscitation of newborn infants with 100% oxygen or air: a systematic review and meta-analysis. Lancet. 2004;364:1329–1333
  43. Saugstad OD, Ramji S, Vento M. Resuscitation of depressed newborn infants with ambient air or pure oxygen: a meta-analysis. Biol Neonate. 2005;87:27–34
  44. Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress: a clinical and electroencephalographic study. Arch Neurol. 1976;33:696–705
  45. Saugstad OD. Optimal oxygenation at birth and in the neonatal period. Neonatology. 2007;91:319–322
  46. Canadian NRP Steering Committee. Recommendations for specific treatment modifications in Canadian context. Addendum to the 2006 NRP textbook, 2006 Canadian Pediatric Society
  47. Australian Resuscitation Council. 2006 Australian Resuscitation Council Guidelines: Section 13 Neonatal Guidelines (2006). http://www.resus.org.auAccessed November 20, 2007
  48. Lindner W, Vossbeck S, Hummler H, et al. Delivery room management of extremely low birth weight infants: spontaneous breathing or intubation?. Pediatrics. 1999;103:961–967
  49. Aly H, Massaro AN, Patel K, et al. Is it safer to intubate premature infants in the delivery room?. Pediatrics. 2005;115:1660–1665
  50. Finer NN, Carlo WA, Duara S, et al. Delivery room continuous positive airway pressure/positive end-expiratory pressure in extremely low birth weight infants: a feasibility trial. Pediatrics. 2004;114:651–657
  51. Harling AE, Beresford MW, Vince GS, et al. Does sustained lung inflation at resuscitation reduce lung injury in the preterm infant?. Arch Dis Child Fetal Neonatal Ed. 2005;90:F406–F410
  52. Dawson J, Kamlin CA, Wong C, et al. Oxygen saturation and heart rate during delivery room resuscitation in infants < 30 weeks gestation with air or 100% oxygen. Arch Dis Child Fetal Neonatal Ed. 2008;Aug 14 (Epub ahead of print. PMID:18703572)
  53. Ramji S, Ahuja S, Thirupuram S, et al. Resuscitation of asphyxic newborn infants with room air or 100% oxygen. Pediatr Res. 1993;34:809–812

PII: S0146-0005(08)00087-6

doi: 10.1053/j.semperi.2008.08.002

Seminars in Perinatology
Volume 32, Issue 5 , Pages 355-366 , October 2008

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