Seminars in Perinatology
Volume 32, Issue 5 , Pages 325-333 , October 2008

Interleukin-1 and Ischemic Brain Injury in the Newborn: Development of a Small Molecule Inhibitor of IL-1 Receptor

  • Christiane Quiniou, MSc

      Affiliations

    • Hôpital Ste. Justine, Research Center, Departments of Pediatrics and Pharmacology, Montreal, Quebec, CA
    • ,
  • Emna Kooli, MSc

      Affiliations

    • Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, CA
    • ,
  • Jean-Sébastien Joyal, MD

      Affiliations

    • Hôpital Ste. Justine, Research Center, Departments of Pediatrics and Pharmacology, Montreal, Quebec, CA
    • ,
  • Przemyslaw Sapieha, PhD

      Affiliations

    • Hôpital Ste. Justine, Research Center, Departments of Pediatrics and Pharmacology, Montreal, Quebec, CA
    • ,
  • Florian Sennlaub, MD, PhD

      Affiliations

    • Inserm, U872, Paris, France
    • ,
  • Isabelle Lahaie, MSc

      Affiliations

    • Hôpital Ste. Justine, Research Center, Departments of Pediatrics and Pharmacology, Montreal, Quebec, CA
    • ,
  • Zhuo Shao, MSc

      Affiliations

    • Hôpital Ste. Justine, Research Center, Departments of Pediatrics and Pharmacology, Montreal, Quebec, CA
    • Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, CA
    • ,
  • Xin Hou, MD, PhD

      Affiliations

    • Hôpital Ste. Justine, Research Center, Departments of Pediatrics and Pharmacology, Montreal, Quebec, CA
    • ,
  • Pierre Hardy, MD, PhD

      Affiliations

    • Hôpital Ste. Justine, Research Center, Departments of Pediatrics and Pharmacology, Montreal, Quebec, CA
    • ,
  • William Lubell, PhD

      Affiliations

    • Department of Chemistry, University of Montreal, Montreal, Quebec, Canada
    • ,
  • Sylvain Chemtob, MD, PhD

      Affiliations

    • Hôpital Ste. Justine, Research Center, Departments of Pediatrics and Pharmacology, Montreal, Quebec, CA
    • Corresponding Author InformationAddress reprint requests to Sylvain Chemtob, MD, PhD, Hôpital Ste. Justine, Research Center, 3175 Côte Ste. Catherine, Montreal, QC, H3T 1C5, CA

References 

  1. McLean C, Ferriero D. Mechanisms of hypoxic-ischemic injury in the term infant. Sem Perinatol. 2004;28:425–432
  2. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1988;1:623–634
  3. Beckman JS, Viera L, Estévez AG, et al. Nitric oxide and peroxynitrite in the perinatal period. Semin Perinatol. 2000;24:37–41
  4. Ferriero DM, Holtzman DM, Black SM, et al. Neonatal mice lacking neuronal nitric oxide synthase are less vulnerable to hypoxic-ischemic injury. Neurobiol Dis. 1996;3:64–71
  5. Sun GY, Horrocks LA, Farooqui AA. The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseases. J Neurochem. 2007;103:1–16
  6. Buonocore G, Perrone S, Bracci R. Free radicals and brain damage in the newborn. Biol Neonate. 2001;79:180–186
  7. Ferriero DM. Oxidant mechanisms in neonatal hypoxia-ischemia. Dev Neurosci. 2001;23:198–202
  8. Chew LJ, Takanohashi A, Bell M. Microglia and inflammation: impact on developmental brain injuries. Ment Retard Dev Disabil Res Rev. 2006;12:105–112
  9. Barone FC, Feuerstein GZ. Inflammatory mediators and stroke: new opportunities for novel therapeutics. J Cereb Blood Flow Metab. 1999;19:819–834
  10. Hedtjarn M, Mallard C, Arvidsson P, et al. White matter injury in the immature brain: role of interleukin-18. Neurosci Lett. 2005;373:16–20
  11. Lucas SM, Rothwell NJ, Gibson RM. The role of inflammation in CNS injury and disease. Br J Pharmacol. 2006;147:S232–S240
  12. Wu YW, Colford JM Jr: Chorioamnionitis as a risk factor for cerebral palsy: a meta-analysis. JAMA 284:1417-1424, 200
  13. Dammann O, Leviton A. Role of the fetus in perinatal infection and neonatal brain damage. Curr Opin Pediatr. 2000;12:99–104
  14. Kadhim H, Tabarki B, Verellen G, et al. Inflammatory cytokines in the pathogenesis of periventricular leukomalacia. Neurology. 2001;56:1278–1284
  15. Arnett HA, Mason J, Marino M, et al. TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci. 2001;4:1116–1122
  16. Loddick SA, Turnbull AV, Rothwell NJ. Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat. J Cereb Blood Flow Metab. 1998;18:176–179
  17. Martin D, Chinookoswong N, Miller G, et al. The interleukin-1 receptor antagonist (rhIL-1ra) protects against cerebral infarction in a rat model of hypoxia-ischemia. Exp Neurol. 1994;130:362–367
  18. Dinarello CA, Gatti S, Bartfai T. Fever: links with an ancient receptor. Curr Biol. 1999;9:R147–R150
  19. Arend WP. Interleukin-1 receptor antagonist. Adv Immunol. 1993;54:167–227
  20. Zhou N, Luo Z, Luo J. Exploring the stereochemistry of CXCR4-peptide recognition and inhibiting HIV-1 entry with D-peptides derived from chemokines. J Biol Chem. 2002;277:17476–17485
  21. McDonnell JM, Beavil AJ, Mackay GA. Structure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptor. Nat Struct Biol. 1996;3:419–426
  22. Quiniou C, Sapieha P, Lahaie I, et al. Development of a novel non-competitive antagonist of Interleukin-1 receptor. J Immunol. 2008;180:6977–6987
  23. Kenakin T. New concepts in drug discovery: collateral efficacy and permissive antagonism. Nat Rev Drug Discov. 2005;4:919–927
  24. Koshland DE. Conformational changes: how small is big enough?. Nat Med. 1998;4:1112–1114
  25. Kenakin T. Allosteric modulators: the new generation of receptor antagonist. Mol Interv. 2004;4:222–229
  26. Gardiner SM, Kemp PA, March JE. The influence of antibodies to TNF-alpha and IL-1beta on haemodynamic responses to the cytokines, and to lipopolysaccharide, in conscious rats. Br J Pharmacol. 1998;125:1543–1550
  27. Rogler G, Andus T. Cytokines in inflammatory bowel disease. World J Surg. 1998;22:382–389
  28. Galvez J, Garrido M, Rodríguez-Cabezas ME, et al. The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production. Inflamm Bowel Dis. 2003;9:363–371
  29. Peterson TC, Cleary CE, Shaw AM. Therapeutic role for bismuth compounds in TNBS-induced colitis in the rat. Dig Dis Sci. 2000;45:466–473
  30. Ljungqvist A, Feng DM, Hook W, et al. Antide and related antagonists of luteinizing hormone release with long action and oral activity. Proc Natl Acad Sci USA. 1988;85:8236–8240
  31. Bae JH, Oh MM, Shim KS. The effects of long-term administration of oral desmopressin on the baseline secretion of antidiuretic hormone and serum sodium concentration for the treatment of nocturia: a circadian study. J Urol. 2007;178:200–203
  32. Rice JE, Vannucci RC, Brierley JB. The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol. 1981;9:131–141
  33. Hardy P, Dumont I, Bhattacharya M, et al. Oxidants, nitric oxide and prostanoids in the developing ocular vasculature: a basis for ischemic retinopathy. Cardiovasc Res. 2000;47:489–509
  34. Sirinyan M, Sennlaub F, Dorfman A, et al. Hyperoxic exposure leads to nitrative stress and ensuing microvascular degeneration and diminished brain mass and function in the immature subject. Stroke. 2006;37:2807–2815
  35. Edwards AD, Tan S. Perinatal infections, prematurity and brain injury. Curr Opin Pediatr. 2006;18:119–124

PII: S0146-0005(08)00083-9

doi: 10.1053/j.semperi.2008.07.001

Seminars in Perinatology
Volume 32, Issue 5 , Pages 325-333 , October 2008

Article Tools

* Image Usage & Resolution