Seminars in Perinatology
Volume 32, Issue 3 , Pages 190-193 , June 2008

Cardiac Changes in the Intrauterine Growth-Restricted Fetus

  • Mert Ozan Bahtiyar, MD

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT.
    • Corresponding Author InformationAddress reprint requests to Mert Ozan Bahtiyar, MD, Section of Maternal–Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, PO Box 208063, New Haven, CT 06520-8063.
    • ,
  • Joshua A. Copel, MD

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT.
    • Department of Pediatrics, Yale University School of Medicine, New Haven, CT.

References 

  1. Froen JF, Gardosi JO, Thurmann A, et al. Restricted fetal growth in sudden intrauterine unexplained death. Acta Obstet Gynecol Scand. 2004;83:801–807
  2. Severi FM, Rizzo G, Bocchi C, et al. Intrauterine growth retardation and fetal cardiac function. Fetal Diagn Ther. 2000;15:8–19
  3. Acharya G, Erkinaro T, Makikallio K, et al. Relationships among Doppler-derived umbilical artery absolute velocities, cardiac function, and placental volume blood flow and resistance in fetal sheep. Am J Physiol Heart Circ Physiol. 2004;286:H1266–H1272
  4. Isaaz K, Ethevenot G, Admant P, et al. A new Doppler method of assessing left ventricular ejection force in chronic congestive heart failure. Am J Cardiol. 1989;64:81–87
  5. Sutton MS, Gill T, Plappert T, et al. Assessment of right and left ventricular function in terms of force development with gestational age in the normal human fetus. Br Heart J. 1991;66:285–289
  6. Tulzer G, Khowsathit P, Gudmundsson S, et al. Diastolic function of the fetal heart during second and third trimester: a prospective longitudinal Doppler-echocardiographic study. Eur J Pediatr. 1994;153:151–154
  7. Tei C, Ling LH, Hodge DO, et al. New index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function: a study in normals and dilated cardiomyopathy. J Cardiol. 1995;26:357–366
  8. Rizzo G, Arduini D. Fetal cardiac function in intrauterine growth retardation. Am J Obstet Gynecol. 1991;165:876–882
  9. Rizzo G, Capponi A, Rinaldo D, et al. Ventricular ejection force in growth-retarded fetuses. Ultrasound Obstet Gynecol. 1995;5:247–255
  10. Kiserud T, Ebbing C, Kessler J, et al. Fetal cardiac output, distribution to the placenta and impact of placental compromise. Ultrasound Obstet Gynecol. 2006;28:126–136
  11. Miyague NI, Ghidini A, Fromberg R, et al. Alterations in ventricular filling in small-for-gestational-age fetuses. Fetal Diagn Ther. 1997;12:332–335
  12. Miyake T. Doppler echocardiographic studies of diastolic cardiac function in the human fetal heart. Kurume Med J. 2001;48:59–64
  13. Rizzo G, Arduini D, Romanini C, et al. Doppler echocardiographic assessment of atrioventricular velocity waveforms in normal and small-for-gestational-age fetuses. Br J Obstet Gynaecol. 1988;95:65–69
  14. Reed KL, Appleton CP, Sahn DJ, et al. Human fetal tricuspid and mitral deceleration time: changes with normal pregnancy and intrauterine growth retardation. Am J Obstet Gynecol. 1989;161:1532–1535
  15. Tsutsumi T, Ishii M, Eto G, et al. Serial evaluation for myocardial performance in fetuses and neonates using a new Doppler index. Pediatr Int. 1999;41:722–727
  16. Veille JC, Hanson R, Sivakoff M, et al. Fetal cardiac size in normal, intrauterine growth retarded, and diabetic pregnancies. Am J Perinatol. 1993;10:275–279
  17. Baschat AA, Gembruch U, Gortner L, et al. Coronary artery blood flow visualization signifies hemodynamic deterioration in growth-restricted fetuses. Ultrasound Obstet Gynecol. 2000;16:425–431
  18. Baschat AA, Gembruch U. Evaluation of the fetal coronary circulation. Ultrasound Obstet Gynecol. 2002;20:405–412
  19. Bauer R, Walter B, Hoppe A, et al. Body weight distribution and organ size in newborn swine (sus scrofa domestica): a study describing an animal model for asymmetrical intrauterine growth retardation. Exp Toxicol Pathol. 1998;50:59–65
  20. Bauer R, Walter B, Gaser E, et al. Cardiovascular function and brain metabolites in normal weight and intrauterine growth restricted newborn piglets: effect of mild hypoxia. Exp Toxicol Pathol. 1998;50:294–300
  21. Battista M-C, Oligny LL, St-Louis J, et al. Intrauterine growth restriction in rats is associated with hypertension and renal dysfunction in adulthood. Am J Physiol Endocrinol Metab. 2002;283:E124–E131
  22. Corstius HB, Zimanyi MA, Maka N, et al. Effect of intrauterine growth restriction on the number of cardiomyocytes in rat hearts. Pediatr Res. 2005;57:796–800
  23. Bubb KJ, Cock ML, Black MJ, et al. Intrauterine growth restriction delays cardiomyocyte maturation and alters coronary artery function in the fetal sheep. J Physiol (Lond). 2007;578:871–881
  24. Xu Y, Williams SJ, O'Brien D, et al. Hypoxia or nutrient restriction during pregnancy in rats leads to progressive cardiac remodeling and impairs postischemic recovery in adult male offspring. FASEB J. 2006;20:1251–1253
  25. Figueras F, Puerto B, Martinez JM, et al. Cardiac function monitoring of fetuses with growth restriction. Eur J Obstet Gynecol Reprod Biol. 2003;110:159–163

PII: S0146-0005(08)00039-6

doi: 10.1053/j.semperi.2008.02.010

Seminars in Perinatology
Volume 32, Issue 3 , Pages 190-193 , June 2008

Article Tools

* Image Usage & Resolution