Seminars in Perinatology
Volume 32, Issue 3 , Pages 178-181 , June 2008

Nutrient Transport Across the Intrauterine Growth-Restricted Placenta

  • Anna Maria Marconi, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Anna Maria Marconi, MD, Department of Obstetrics and Gynecology, DMSD San Paolo, University of Milano, Via A. di Rudinì 8, 20142 Milano, Italy.
    • ,
  • Cinzia L. Paolini, MD

References 

  1. Battaglia FC, Meschia G. An introduction to fetal physiology. Orlando, FL: Academic Press; 1986;
  2. Jones HN, Powell TL, Jansson T. Regulation of placental nutrient transport: a review. Placenta. 2007;28:763–774
  3. Pardi G, Marconi AM, Cetin I. Placental-fetal interrelationshiop in IUGR fetuses: a review. Placenta. 2002;23(suppl A):S136–S141
  4. Pardi G, Marconi AM, Cetin I, et al. Diagnostic value of blood sampling in fetuses with growth retardation. N Engl J Med. 1993;328:692–696
  5. Marconi AM, Paolini CL, Zerbe G, et al. Lactacidemia in intrauterine growth restricted (IUGR) pregnancies: relationship to clinical severity, oxygenation and placental weight. Pediatr Res. 2006;59:570–574
  6. Jansson T, Powell TL. Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches. Clin Sci. 2007;113:1–13
  7. Hay WW. Glucose metabolism in the fetal-placental unit. In:  Cowett RM editors. Principles of Perinatal–Neonatal Metabolism. (ed 1). New York, NY: Springer-Verlag; 1991;p. 250–275
  8. Marconi AM, Paolini CL, Buscaglia M, et al. The impact of gestational age and of fetal growth upon the maternal-fetal glucose concentration difference. Obstet Gynecol. 1996;87:937–942
  9. Simmons MA, Meschia G, Makowski EL, et al. Fetal metabolic response to maternal starvation. Pediatr Res. 1970;8:830–836
  10. Marconi AM, Cetin I, Davoli E, et al. An evaluation of fetal glucogenesis in intrauterine growth-retarded pregnancies. Metabolism. 1993;42:860–864
  11. Regnault TRH, de Vrijer B, Battaglia FC. Transport and metabolism of amino acids in placenta. Endocrine. 2002;19:23–41
  12. Marconi AM, Paolini CL, Stramare L, et al. Steady state maternal-fetal leucine enrichments in normal and intrauterine growth-restricted pregnancies. Pediatr Res. 1999;46:114–119
  13. Paolini CL, Marconi AM, Ronzoni S, et al. Placental transport of leucine, phenylalanine, glycine and proline in intrauterine growth restricted pregnancies. J Clin Endocrinol Metab. 2001;86:5427–5432
  14. Ronzoni S, Marconi AM, Cetin I, et al. Umbilical amino acid uptake at increasing maternal amino acid concentrations: effect of a commercial maternal amino acid infusate. Am J Obstet Gynecol. 1999;181:477–483
  15. Ronzoni S, Marconi AM, Paolini CL, et al. The effect of a maternal infusion of amino acids on umbilical uptake in pregnancies complicated by intrauterine growth restriction. Am J Obstet Gynecol. 2001;187:741–746
  16. Galan HL, Marconi AM, Paolini CL, et al. Placental transport of essential amino acids in human pregnancy: an in vivo study. J Soc Gynecol Invest. 2006;13:77A
  17. Cetin I, Giovannini N, Alvino G, et al. Intrauterine growth restriction is associated with changes in polyunsaturated fatty acid fetal–maternal relationships. Pediatr Res. 2002;52:750–755
  18. Tabano S, Alvino G, Antonazzo P, et al. Placental LPL gene expression is increased in severe intrauterine growth-restricted pregnancies. Pediatr Res. 2006;59:250–253

PII: S0146-0005(08)00036-0

doi: 10.1053/j.semperi.2008.02.007

Seminars in Perinatology
Volume 32, Issue 3 , Pages 178-181 , June 2008

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