Seminars in Perinatology
Volume 31, Issue 6 , Pages 332-338 , December 2007

Fertility and Reproductive Disorders in Female Solid Organ Transplant Recipients

  • Nataki C. Douglas, MD, PhD

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Columbia University, New York, NY.
    • Corresponding Author InformationAddress reprint requests to Nataki C. Douglas, MD, PhD, 622 West 168th Street, PH 16-69, New York, NY 10032.
    • ,
  • Monrji Shah, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Columbia University, New York, NY.
    • ,
  • Mark V. Sauer, MD

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Columbia University, New York, NY.

References 

  1. Armenti VT, Radomski JS, Moritz MJ, et al. Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation. Clin Transpl. 2004;103–114
  2. Radomski JS, Ahlswede BA, Jarrell BE, et al. Outcomes of 500 pregnancies in 335 female kidney, liver, and heart transplant recipients. Transplant Proc. 1995;27:1089–1090
  3. Diemont WL, Vruggink PA, Meuleman EJ, et al. Sexual dysfunction after renal replacement therapy. Am J Kidney Dis. 2000;35:845–851
  4. Lessan-Pezeshki M. Pregnancy after renal transplantation: points to consider. Nephrol Dial Transplant. 2002;17:703–707
  5. van Diemen-Steenvoorde R, Donckerwolcke RA, Brackel H, et al. Growth and sexual maturation in children after kidney transplantation. J Pediatr. 1987;110:351–356
  6. Sucato GS, Murray PJ. Gynecologic health care for the adolescent solid organ transplant recipient. Pediatr Transplant. 2005;9:346–356
  7. Ferraris JR, Domene HM, Escobar ME, et al. Hormonal profile in pubertal females with chronic renal failure: before and under haemodialysis and after renal transplantation. Acta Endocrinol (Copenh). 1987;115:289–296
  8. Handelsman DJ, Dong Q. Hypothalamo-pituitary gonadal axis in chronic renal failure. Endocrinol Metab Clin North Am. 1993;22:145–161
  9. Kim JH, Chun CJ, Kang CM, et al. Kidney transplantation and menstrual changes. Transplant Proc. 1998;30:3057–3059
  10. Lim VS, Henriquez C, Sievertsen G, et al. Ovarian function in chronic renal failure: evidence suggesting hypothalamic anovulation. Ann Intern Med. 1980;93:21–27
  11. Goodwin NJ, Valenti C, Hall JE, et al. Effects of uremia and chronic hemodialysis on the reproductive cycle. Am J Obstet Gynecol. 1968;100:528–535
  12. Perez RJ, Lipner H, Abdulla N, et al. Menstrual dysfunction of patients undergoing chronic hemodialysis. Obstet Gynecol. 1978;51:552–555
  13. Zingraff J, Jungers P, Pelissier C, et al. Pituitary and ovarian dysfunctions in women on haemodialysis. Nephron. 1982;30:149–153
  14. Gomez F, de la Cueva R, Wauters JP, et al. Endocrine abnormalities in patients undergoing long-term hemodialysis (The role of prolactin). Am J Med. 1980;68:522–530
  15. Sievertsen GD, Lim VS, Nakawatase C, et al. Metabolic clearance and secretion rates of human prolactin in normal subjects and in patients with chronic renal failure. J Clin Endocrinol Metab. 1980;50:846–852
  16. Pietrzak B, Marianowski L, Gradowska L. [Ovarian function in women after kidney transplantation]. Wiad Lek. 1994;47:625–628
  17. Tauchmanova L, Carrano R, Sabbatini M, et al. Hypothalamic-pituitary-gonadal axis function after successful kidney transplantation in men and women. Hum Reprod. 2004;19:867–873
  18. Yildirim Y, Tinar S, Yildirim YK, et al. Comparison of pituitary-ovarian function in patients who have undergone successful renal transplantation and healthy women. Fertil Steril. 2005;83:1553–1556
  19. Pezeshki M, Taherian AA, Gharavy M, et al. Menstrual characteristics and pregnancy in women after renal transplantation. Int J Gynaecol Obstet. 2004;85:119–125
  20. Pietrzak B, Wielgos M, Kaminski P, et al. Menstrual cycle and sex hormone profile in kidney-transplanted women. Neuro Endocrinol Lett. 2006;27:198–202
  21. Pietrzak B, Cyganek A, Jabiry-Zieniewicz Z, et al. Function of the ovaries in female kidney transplant recipients. Transplant Proc. 2006;38:180–183
  22. Lessan-Pezeshki M, Ghazizadeh S, Khatami MR, et al. Fertility and contraceptive issues after kidney transplantation in women. Transplant Proc. 2004;36:1405–1406
  23. Rinella ME. Pregnancy after liver transplantation. Ann Hepatol. 2006;5:212–215
  24. Viner RM, et al. Growth of long-term survivors of liver transplantation. Arch Dis Child. 1999;80:235–240
  25. Sucato GS, Murray PJ. Developmental and reproductive health issues in adolescent solid organ transplant recipients. Semin Pediatr Surg. 2006;15:170–178
  26. Laifer SA, Guido RS. Reproductive function and outcome of pregnancy after liver transplantation in women. Mayo Clin Proc. 1995;70:388–394
  27. Cundy TF, O’Grady JG, Williams R. Recovery of menstruation and pregnancy after liver transplantation. Gut. 1990;31:337–338
  28. de Koning ND, Haagsma EB. Normalization of menstrual pattern after liver transplantation: consequences for contraception. Digestion. 1990;46:239–241
  29. Cundy TF, Butler J, Pope RM, et al. Amenorrhoea in women with non-alcoholic chronic liver disease. Gut. 1991;32:202–206
  30. Stellon AJ, Williams R. Increased incidence of menstrual abnormalities and hysterectomy preceding primary biliary cirrhosis. Br Med J (Clin Res Ed). 1986;293:297–298
  31. Van Thiel DH, Lester R. The effect of chronic alcohol abuse on sexual function. Clin Endocrinol Metab. 1979;8:499–510
  32. Hugues JN, Perret G, Adessi G, et al. Effects of chronic alcoholism on the pituitary-gonadal function of women during menopausal transition and in the post menopausal period. Biomedicine. 1978;29:279–283
  33. Jung Y, Russfield AB. Prolactin cells in the hypophysis of cirrhotic patients. Arch Pathol. 1972;94:265–269
  34. Gordon GG, Olivo J, Rafil F, et al. Conversion of androgens to estrogens in cirrhosis of the liver. J Clin Endocrinol Metab. 1975;40:1018–1026
  35. Mass K, Quint EH, Punch MR, et al. Gynecological and reproductive function after liver transplantation. Transplantation. 1996;62:476–479
  36. Christopher V, Al-Chalabi T, Richardson PD, et al. Pregnancy outcome after liver transplantation: a single-center experience of 71 pregnancies in 45 recipients. Liver Transpl. 2006;12:1138–1143
  37. Hunt SA. Pregnancy in heart transplant recipients: a good idea?. J Heart Lung Transplant. 1991;10:499–503
  38. Baron O, Hubaut J, Galetta D, et al. Pregnancy and heart-lung transplantation. J Heart Lung Transplant. 2002;21:914–917
  39. de Broux E, Huot CH, Chartrand S, et al. Growth and pubertal development following pediatric heart transplantation: a 15-year experience at Ste-Justine Hospital. J Heart Lung Transplant. 2000;19:825–833
  40. Edenborough FP. Women with cystic fibrosis and their potential for reproduction. Thorax. 2001;56:649–655
  41. Murray JE, Reid DE, Harrison JH, et al. Successful pregnancies after human renal transplantation. N Engl J Med. 1963;269:341–343
  42. Armenti VT, Gertner GS, Eisenberg JA, et al. National transplantation Pregnancy Registry: outcomes of pregnancies in lung recipients. Transplant Proc. 1998;30:1528–1530
  43. Troche V, Ville Y, Fernandez H. Pregnancy after heart or heart-lung transplantation: a series of 10 pregnancies. Br J Obstet Gynaecol. 1998;105:454–458
  44. Gyi KM, Hodson ME, Yacoub MY. Pregnancy in cystic fibrosis lung transplant recipients: case series and review. J Cyst Fibros. 2006;5:171–175
  45. Lockwood GM, Ledger WL, Barlow DH. Successful pregnancy outcome in a renal transplant patient following in-vitro fertilization. Hum Reprod. 1995;10:1528–1530
  46. Furman B, Wiznitzer A, Hackmon R, et al. Multiple pregnancies in women after renal transplantation (Case report that rises a management dilemma). Eur J Obstet Gynecol Reprod Biol. 1999;84:107–110
  47. Khalaf Y, Elkington N, Anderson H, et al. Ovarian hyperstimulation syndrome and its effect on renal function in a renal transplant patient undergoing IVF treatment: case report. Hum Reprod. 2000;15:1275–1277
  48. Tamaki M, Ami M, Kimata N, et al. Successful singleton pregnancy outcome resulting from in vitro fertilization after renal transplantation. Transplantation. 2003;75:1082–1083
  49. Case AM, Weissman A, Sermer M, et al. Successful twin pregnancy in a dual-transplant couple resulting from in-vitro fertilization and intracytoplasmic sperm injection: case report. Hum Reprod. 2000;15:626–628
  50. Ulug U, Mesut A, Jozwiak EA, et al. Successful pregnancy in a liver transplant recipient following controlled ovarian hyperstimulation and intracytoplasmic sperm injection. J Assist Reprod Genet. 2005;22:311–313
  51. Beauchamp TL, Childress JF. Principles of Biomedical Ethics. New York, NY: Oxford University Press; 1994;
  52. Beauchamp TL. Methods and principles in biomedical ethics. J Med Ethics. 2003;29:269–274
  53. Davison JM. Dialysis, transplantation, and pregnancy. Am J Kidney Dis. 1991;17:127–132
  54. Cardonick E, Moritz M, Armenti V. Pregnancy in patients with organ transplantation: a review. Obstet Gynecol Surv. 2004;59:214–222
  55. McKay DB, Josephson MA. Pregnancy in recipients of solid organs: effects on mother and child. N Engl J Med. 2006;354:1281–1293
  56. Ross LF. Ethical considerations related to pregnancy in transplant recipients. N Engl J Med. 2006;354:1313–1316
  57. Dickey RP, Holtkamp DE. Development, pharmacology and clinical experience with clomiphene citrate. Hum Reprod Update. 1996;2:483–506
  58. Hughes E, Collins J, Vandekerckhove P. Clomiphene citrate for unexplained subfertility in women. Cochrane Database Syst Rev. 2000;CD000057
  59. Mitwally MF, Casper RF. Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate. Fertil Steril. 2001;75:305–309
  60. Mitwally MF, Biljan MM, Casper RF. Pregnancy outcome after the use of an aromatase inhibitor for ovarian stimulation. Am J Obstet Gynecol. 2005;192:381–386
  61. Gleicher N, Oleske DM, Tur-Kaspa I, et al. Reducing the risk of high-order multiple pregnancy after ovarian stimulation with gonadotropins. N Engl J Med. 2000;343:2–7
  62. Tur R, et al. Risk factors for high-order multiple implantation after ovarian stimulation with gonadotrophins: evidence from a large series of 1878 consecutive pregnancies in a single centre. Hum Reprod. 2001;16:2124–2129
  63. Stone J, Eddleman K, Lynch L, et al. A single center experience with 1000 consecutive cases of multifetal pregnancy reduction. Am J Obstet Gynecol. 2002;187:1163–1167
  64. Dodd J, Crowther C. Multifetal pregnancy reduction of triplet and higher-order multiple pregnancies to twins. Fertil Steril. 2004;81:1420–1422
  65. De Geyter C, De Geyter M, Nieschlag E. Low multiple pregnancy rates and reduced frequency of cancellation after ovulation induction with gonadotropins, if eventual supernumerary follicles are aspirated to prevent polyovulation. J Assist Reprod Genet. 1998;15:111–116
  66. Albano C, Platteau P, Noqueira D, et al. Avoidance of multiple pregnancies after ovulation induction by supernumerary preovulatory follicular reduction. Fertil Steril. 2001;76:820–822
  67. Nisker J, Tummon I, Daniel S, et al. Conversion of cycles involving ovarian hyperstimulation with intra-uterine insemination to in-vitro fertilization. Hum Reprod. 1994;9:406–408
  68. Antman AM, Politch JA, Ginsburg ES. Conversion of high-response gonadotropin intrauterine insemination cycles to in vitro fertilization results in excellent ongoing pregnancy rates. Fertil Steril. 2002;77:715–720
  69. Edris F, Kerner CM, Feyles V, et al. Successful management of an extensive intracranial sinus thrombosis in a patient undergoing IVF: case report and review of literature. Fertil Steril. 2007;88:705.e9;e14
  70. Waldenstrom U, Kahn J, Marsk L, et al. High pregnancy rates and successful prevention of severe ovarian hyperstimulation syndrome by “prolonged coasting” of very hyperstimulated patients: a multicentre study. Hum Reprod. 1999;14:294–297
  71. Levinsohn-Tavor O, Friedler S, Schacter M, et al. Coasting: what is the best formula?. Hum Reprod. 2003;18:937–940
  72. Kosasa TS, McNamee PI, Morton C, et al. Pregnancy rates after transfer of cryopreserved blastocysts cultured in a sequential media. Am J Obstet Gynecol. 2005;192:2035–2039discussion 2039-2040
  73. Wang JG, Douglas NC, Dicken C, et al. Cryopreservation of supernumerary high quality embryos predicts favorable outcomes for patients undergoing repeated cycles of in vitro fertilization. Fertil Steril. 2007;May 15 (Epub ahead of print)
  74. Veeck LL, Bodine R, Clarke RN, et al. High pregnancy rates can be achieved after freezing and thawing human blastocysts. Fertil Steril. 2004;82:1418–1427
  75. Ryan GL, Sparks AE, Sipe CS, et al. A mandatory single blastocyst transfer policy with educational campaign in a United States IVF program reduces multiple gestation rates without sacrificing pregnancy rates. Fertil Steril. 2007;88:354–360

PII: S0146-0005(07)00106-1

doi: 10.1053/j.semperi.2007.09.002

Seminars in Perinatology
Volume 31, Issue 6 , Pages 332-338 , December 2007

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