Seminars in Perinatology
Volume 31, Issue 4 , Pages 204-207 , August 2007

Implantation and Early Embryonic Development: Implications for Pregnancy

  • Danielle Vitiello, PhD, MD
    • ,
  • Pasquale Patrizio, MD, MBE

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Pasquale Patrizio, MD, MBE, Yale University School of Medicine, Yale Fertility Center, Department of Obstetrics, Gynecology and Reproductive Sciences, 150 Sargeant Drive, New Haven, CT 06511.

References 

  1. Aplin JD. The cell biological basis of human implantation. Best Pract Res Clin Obstet Gynaecol. 2000;14:757–764
  2. Hamilton WJ, Boyd JD. Trophoblast in human utero-placental arteries. Nature. 1966;212:906–908
  3. Janatpour MJ, Cross JC, Rossant J, et al. A repertoire of differentially expressed transcription factors that offers insight into mechanisms of human cytotrophoblast differentiation. Dev Genet. 1999;25:146–157
  4. Achache HRA. Endometrial receptivity markers, the journey to successful embryo implantation. Hum Reprod Update. 2006;12:731–746
  5. Enders A. Trophoblast-uterine interactions in the first days of implantation: models for the study of implantation events in the human. Sem Reprod Med. 2000;18:255–263
  6. Norwitz E, Schust DJ, Fisher SJ. Implantation and the survival of early pregnancy. N Engl J Med. 2001;345:1400–1408
  7. Red-Horse K, Zhou Y, Genbacev O, et al. Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J Clin Invest. 2004;114:744–754
  8. Carson DD, Lagow E, Thathiah A, et al. Changes in gene expression during the early to mid-luteal (receptive phase) transition in human endometrium detected by high-density microarray screening. Mol Hum Reprod. 2002;8:871–879
  9. Kao LC, Tulac S, Lobo S, et al. Global gene profiling in human endometrium during the window of implantation. Endocrinology. 2002;143:2119–2138
  10. Rossant J, Cross JC. Placental development: lessons from mouse mutants. Nat Rev Genet. 2001;2:538–548
  11. Cross JC. How to make a placenta: mechanisms of trophoblast cell differentiation in mice: a review. Placenta. 2005;26(suppl A):S4–S9
  12. Carter AM. Animal models of human placentation: a review. Placenta. 2007;28(suppl A):S129–S132
  13. Cross JC, Baczyk D, Dobric N, et al. Genes, development and evolution of the placenta. Placenta. 2003;24:123–130
  14. Larue L, Obsugi M, Hirchenhain J, et al. E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc Natl Acad Sci U S A. 1994;91:8263–8267
  15. Nichols J, Zevnik B, Anastassiadis , et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell. 1998;95:379–391
  16. Niwa H, Toyooka Y, Shimosato D, et al. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell. 2005;123:917–929
  17. Hay DC, Sutherland L, Clark J, et al. Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells. Stem Cells. 2004;22:225–235
  18. Genbacev O, Zhou Y, Ludlow JW, et al. Regulation of human placental development by oxygen tension. Science. 1997;277:1669–1672
  19. Aplin JD, Howe A, Alahari SK, et al. Signal transduction and signal modulation by cell adhesion receptors, the role of integrins, cadherins, immunoglobulin-cell adhesion molecules and selectins. Pharmacol Rev. 1998;50:197–263
  20. Ferretti C, Bruni L, Dangles-Marie V, et al. Molecular circuits shared by placental and cancer cells, and their implications in the proliferative, invasive and migratory capacities of trophoblasts. Hum Reprod Update. 2007;13:121–141
  21. Genbacev OD, Prakobphol A, Foulk RA, et al. Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science. 2003;299:450–458
  22. Prakobphol A, Genbacev O, Gormley , et al. A role for the L-selectin adhesion system in mediating cytotrophoblast emigration from the placenta. Dev Biol. 2006;298:107–117
  23. Rosen SD. Ligands for L-selectin: homing, inflammation, and beyond. Annu Rev Immunol. 2004;22:129–156
  24. Thathiah A, Dharmaraj N, Julian JJ, et al. Tumor necrosis factor alpha stimulates MUC1 synthesis and ectodomain release in a human uterine epithelial cell line. Endocrinology. 2004;145:4192–4203
  25. Meseguer M, Aplin JD, Caballero-Campo P, et al. Human endometrial mucin MUCI is up regulated by progesterone and down regulated in vitro by the human blastocyst. Biol Reprod. 2001;64:590–601
  26. Pijnenborg R. Implantation and immunology: maternal inflammatory and immune cellular responses to implantation and trophoblast invasion. Reprod Biomed Online. 2002;4(suppl 3):14–17
  27. Salto S. Cytokine cross-talk between mother and embryo/placenta. J Reprod Immunol. 2001;52:15–33
  28. Caniggia I, Taylor CV, Ritchie JW, et al. Endoglin regulates trophoblast differentiation along the invasive pathway in human placental villous explants. Endocrinology. 1997;138:4977–4988
  29. Leisser C, Saleh L, Haider S, et al. Tumor necrosis factor-alpha impairs chorionic gonadotropin beta-subunit expression and cell fusion of human villous cytotrophoblasts. Mol Hum Reprod. 2006;12:601–609
  30. Sargent IL, Borzychowski AM, Redman CW. NK cells and human pregnancy: an inflammatory review. Trends Immunol. 2006;27:399–404
  31. Lunghi L, Ferretti ME, Medici S, et al. Control of human trophoblast function. Reprod Bio Endocrinol. 2007;5:6–11
  32. Zhou U, Fisher SJ, Jantapour M, et al. Human cytotrophoblasts adopt a vascular phenotype as they differentiate (A strategy for successful endovascular invasion?). J Clin Invest. 1997;99:2139–2151
  33. Jauniaux E, Gulbis B, Burton JG. The human first trimester gestational sac limits rather than facilitates oxygen transfer to the foetus: a review. Placenta. 2003;24(suppl A):86–93
  34. Ness RB, Sibai BM. Shared and disparate components of the pathophysiologies of fetal growth restriction and preeclampsia. Am J Obstet Gynecol. 2006;195:40–49
  35. Pijnenborg R, Vercruysse L, Hanssens MT. The uterine spiral arteries in human pregnancy: facts and controversies. Placenta. 2006;27:939–958
  36. Papageorghiou AT, Yu CK, Nicolaides KH. The role of uterine artery Doppler in predicting adverse pregnancy outcome. Best Pract Res Clin Obstet Gynaecol. 2004;18:383–396
  37. Ricci S, Tortoli P, Urban G, et al: A novel US method for the assessment of maternal, placental and fetal circulation during pregnancy. Ultrasonics 2007, in press
  38. Lala PK, Chakraborty C. Factors regulating trophoblast migration and invasiveness: possible derangements contributing to preeclampsia and fetal injury. Placenta. 2003;24:575–587
  39. Kaufmann P, Black S, Huppertz B. Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth restriction. Biol Reprod. 2003;69:1–7
  40. Bambi G, Morganti T, Ricci S, et al. A novel ultrasound instrument for investigation of arterial mechanics. Ultrasonics. 2004;42:731–737
  41. Urban G, Ricci S, Guidi F, et al. Realtime human fetal aorta velocity profile using global acquisition and signal processing (GASP). Ultrasound Obstet Gynecol. 2006;27:716–718

PII: S0146-0005(07)00065-1

doi: 10.1053/j.semperi.2007.05.006

Seminars in Perinatology
Volume 31, Issue 4 , Pages 204-207 , August 2007

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