Seminars in Perinatology
Volume 30, Issue 2 , Pages 89-97 , April 2006

Kernicterus in Late Preterm Infants Cared for as Term Healthy Infants

  • Vinod K. Bhutani, MD

      Affiliations

    • Department of Neonatal and Developmental Medicine, Lucile Salter Packard Children’s Hospital, Stanford University, Palo Alto, CA.
    • Corresponding Author InformationAddress reprint requests to Vinod K. Bhutani, MD, Stanford University School of Medicine, 300 Pasteur Drive, Grant Building, S-226, Palo Alto, CA 94305.
    • ,
  • Lois Johnson, MD

      Affiliations

    • Department of Pediatrics, University of Pennsylvania, Philadelphia, PA.

References 

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  2. Maisels MJ , Baltz RD , Bhutani VK , et al.  American Academy of Pediatrics. Subcommittee on Hyperbilirubinemia   Clinical practice guideline (management of hyperbilirubinemia in the newborn infant ≥35 weeks of gestation) . Pediatrics . 2004; (in press). Available at: http://www.aap.org/jaundice guidelines.htm
  3. Johnson LH , Bhutani VK . Guidelines for management of neonatal jaundice . Clin Perinatol . 1998;25:555–574
  4. Newman TB , Xiong B , Gonzales VM , et al.   Prediction and prevention of extreme neonatal hyperbilirubinemia in a mature health maintenance organization . Arch Pediatr Adolesc Med . 2000;154:1140–1147
  5. Ip S , et al.  American Academy of Pediatrics Subcommittee on Hyperbilirubinemia   An evidence-based review of important issues concerning neonatal hyperbilirubinemia . Pediatrics . 2004;114:e130–e153
  6. Keren R , Bhutani V , Luan X , et al.   Identifying newborns at risk of significant hyperbilirubinemia . Arch Dis Child . 2005;90:415–421
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  8. AAP Subcommittee on Neonatal Hyperbilirubinemia . Commentary (jaundice and kernicterus) . Pediatrics . 2001;108:763–765
  9. JCAHO . Revised guidance to help prevent kernicterus . Sentinel Event Alert . 2004;31:1–2
  10. Brown AK , Johnson L . Loss of concern about jaundice and the reemergence of kernicterus in full-term infants in the era of managed care . In:  Fanaroff AA ,  Klaus MH editor. The Year Book of Neonatal and Perinatal Medicine . Philadelphia, PA: Mosby Yearbook; 1996;p. xvii–xxviii
  11. Johnson LH , Brown AK , Bhutani VK . System-based approach to management of neonatal jaundice and prevention of Kernicterus . J Pediatr . 2002;140:396–403
  12. Bhutani VK , Johnson LH , Maisels MJ , et al.   Kernicterus (epidemiological strategies for its prevention through systems-based approaches) . J Perinatol . 2004;24:650–662
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  15. Volpe JJ . Bilirubin and brain injury . In: Neurology of the Newborn . (ed 4). Philadelphia: Saunders; 2001;p. 521–546
  16. Perlstein M . Neurologic sequelae of erythroblastosis fetalis . Am J Dis Child . 1950;79:605–606
  17. Watchko JF , Claassen D . Kernicterus in premature infants (current prevalence and relationship to NICHD Phototherapy Study exchange criteria) . Pediatrics . 1994;93:996–999
  18. Manning D . American Academy of Pediatrics guidelines for detecting neonatal hyperbilirubinaemia and preventing kernicterus . Arch Dis Child Fetal Neonatal Ed . 2005;90:F450–F451
  19. Ebbesen F , Andersson C , Verder H , et al.   Extreme hyperbilirubinaemia in term and near-term infants in Denmark . Acta Paediatr . 2005;94:59–64
  20. Newman TB , Liljestrand P , Escobar GJ . Infants with bilirubin levels of 30 mg/dL or more in a large managed care organization . Pediatrics . 2003;111:1303–1311
  21. Wennberg RP , Ahlfors CE , Bhutani VK , et al.   Toward understanding kernicterus (a challenge to improve the management of jaundiced newborns) . Pediatrics . 2006;117:474–485
  22. Bhutani VK , Johnson LH , Keren R . Diagnosis and management of hyperbilirubinemia in the term neonate (for a safer first week) . Pediatr Clin North Am . 2004;51:843–861
  23. McDonagh AF , Maisels MJ . Bilirubin unbound (deja vu all over again?) . Pediatrics . 2006;117:523–525
  24. Bhutani VK , Johnson L , Sivieri EM . Predictive ability of a pre-discharge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns . Pediatrics . 1999;103:6–14
  25. Ives NK . Kernicterus in preterm infants; lest we forget (to turn on the lights) . Pediatrics . 1992;90:757–759

PII: S0146-0005(06)00048-6

doi: 10.1053/j.semperi.2006.04.001

Seminars in Perinatology
Volume 30, Issue 2 , Pages 89-97 , April 2006

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